NCTU
Newcastle Neurosurgery Clinical Trials Unit

Neurosurgical Clinical Trial Unit
Neurosurgical Clinical Trial Unit - TOPSAT

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TOPSAT

TOPSAT

Pilot study comparing early endovascular treatment of aneurysm versus treatment after clinical recovery of patients admitted with WFNS grade IV and V subarachnoid haemorrhage.

TOPSAT is a single centre pilot study aimed at comparing early endovascular treatment of aneurysm versus treatment after clinical recovery of patients admitted with WFNS grade IV and V subarachnoid haemorrhage in ITU. 36 patients will be recruited from NGH site over a period of 2 years.

Brief inclusion / exclusion criteria

Inclusion:

  • Proven SAH (proof either by CT or unequivocally positive cerebrospinal fluid study) with WFNS grade IV or V
  • Patient randomised within 24 hours of admission to ITU
  • Patient haemodynamically stable
  • Age between 18 and 75 years
  • Assent obtained from the next of kin for the procedure and the trial

    • Exclusion:

  • Signs of coning or brain death (for e.g. fixed dilated pupil) - not promptly reversed by anti-cerebral oedema treatment
  • Pure intraventricular haemorrhage
  • Large intracerebral haematoma which requires immediate clot evacuation
  • Lack of clinical equipoise
  • Age outside range
  • Pregnancy
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    Staff Involved

    Principal Investigators:

    Dr.D. Mitra

    		 Trial Co-ordinator: Mrs. N. Hind

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    Last updated 16 July 2008
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