NCTU
Newcastle Neurosurgery Clinical Trials Unit

Neurosurgical Clinical Trial Unit
Neurosurgical Clinical Trial Unit - ISUIA

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ISUIA

ISUIA
IN FOLLOW-UP

International multi-centre epidemiological study to gain a better understanding of the natural history of unruptured intracranial aneurysms (UIA).

ISUIA is an epidemiological cohort study. The trial is now in phase III, a continuation prospective study following the treatment outcomes and risks of UIA rupture.

Brief inclusion / exclusion criteria

Inclusion:

  • Patients must have had at least one UIA
  • Patients may have had another aneurysm that was clipped, trapped or coiled
  • Patients must be able to care for themselves (Rankin grade 1 or 2)
  • Observed for 30 days from initial arteriographic demonstration of UIA to operation

    • Exclusion:

  • Fusiform, traumatic or mycotic aneurysms are ineligible
  • Saccular aneurysms <2mm in diameter
  • Patients with a history of intracranial haemorrhage due to underlying structural lesion, nonaneurysmal SAH of unknow aetiology
  • Patients do not consent to long-term follow-up
  • Moribund condition on admission (defined as a patient that is in such a poor clinical condition that further active neurosurgical management would not be anticipated)
    		•
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    Staff Involved

    Principal Investigators:

    Mr. R. Sengupta
    Dr. D. Bates
    Dr.A. Gholkar

    		 Assigned Registrar:

    Associated Staff:

    Dee Frost (Research Nurse)

    Brains

    Last updated 29 Jan 2008
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