Molecular and Cellular Evolution of Microbial Eukaryotes
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Newcastle
EMBO World 09
Molecular Evolution Workshop 2010
Trachipleistophora hominis

Dr. Sirintra Nakjang

Contact information

  • Phone number: +44 (0)191 222 7856
  • e-mail adress: Sirintra.Nakjang (at) newcastle.ac.uk

Work description

I carried out my PhD research at Newcastle University under the supervision of Dr. Robert Hirt and Prof. Anil Wipat. The main aim of my PhD project was to gain a better understanding of host-microbe interactions, particularly focusing on an in-silico identification of microbial extracytoplasmic protein sequences that may play important roles in the interactions at the host-mucosal surfaces. The project involved the development of a systematic, high-throughput sequence analysis workflow to automate the analysis of all available proteomes.

Currently, I am a research associate at Newcastle University and work in a lab jointly run by Prof. Martin Embley and Dr. Robert Hirt. My current work includes the analysis of a new Microsporidia genome sequence, Trachipleistophora hominis and a comparative genome analysis to understand the evolutionary differences among the Microsporidian linages. My research interests include sequence analysis, comparative genomics, high-throughput analysis workflow development, metabolic pathway reconstruction, evolution of parasites, host-microbe interaction.

Sirintra 's publications

  • Alsmark C, Foster PG, Sicheritz-Ponten T, Nakjang S, Embley TM, Hirt RP. Patterns of prokaryotic lateral gene transfers affecting parasitic microbial eukaryotes. Genome Biol. vol 14 (2013). pubmed
  • Nakjang S, Williams TA, Heinz E, Watson AK, Foster PG, Sendra KM, Heaps SE, Hirt RP, Embley TM. Reduction and expansion in microsporidian genome evolution: new insights from comparative genomics. Genome Biol Evol. vol 5 p. 2285-303 (2013). pubmed
  • Collison M, Hirt RP, Wipat A, Nakjang S, Sanseau P, Brown JR. Data mining the human gut microbiota for therapeutic targets. Brief Bioinform. epub (2012). pubmed
  • Flanagan K, Nakjang S, Hallinan J, Harwood C, Hirt RP, Pocock MR, Wipat A. Microbase2.0: a generic framework for computationally intensive bioinformatics workflows in the cloud . J Integr Bioinform. vol 9 p. doi: 10.2390 (2012). pubmed
  • Heinz E, Williams TA, Nakjang S, Noel CJ, Swan DC, Goldberg AV, Harris SR, Weinmaier T, Markert S, Becher D, Bernhardt J, Dagan T, Hacker C, Lucocq JM, Schweder T, Rattei T, Hall N, Hirt RP, Embley TM. The Genome of the Obligate Intracellular Parasite Trachipleistophora hominis: New Insights into Microsporidian Genome Dynamics and Reductive Evolution. PLoS Pathog. vol 8 p. e1002979 (2012). pubmed
  • Nakjang S, Ndeh AN, Wipat A, Bolam DN, Hirt RP. A Novel Extracellular Metallopeptidase Domain Shared by Animal Host-Associated Mutualistic and Pathogenic Microbes. PLoS ONE. vol 7 p. doi: 10.1371 (2012). pubmed
  • Hirt RP, de Miguel N, Nakjang S, Dessi D, Liu YC, Diaz N, Rappelli P, Acosta-Serrano A, Fiori PL, Mottram JC. Trichomonas vaginalis Pathobiology New Insights from the Genome Sequence. Adv Parasitol. vol 77 p. 87-140 (2011). pubmed
  • Kolluru B, Nakjang S, Hirt RP, Wipat A, Ananiadou S. Automatic extraction of microorganisms and their habitats from free text using mining workflows. J Integr Bioinform. vol 8 p. 184 (2011). pubmed