Reema Haifa Hameed Sulthan

• Clozapine Therapy Optimisation: A Comprehensive Review of its Pharmacokinetics to Guide Modelling Strategies
• MBBS

Clozapine is the drug of choice for treatment-resistant schizophrenia. However, the level of clozapine in the body varies significantly among individuals, even at the same dosage. This underscores the importance of understanding the factors that influence how the drug is absorbed and utilized. During this scholarship, I extensively studied how the body processes the drug and reviewed various dosing models aimed at customizing doses for each patient. I also gained skills in Structured Query Language (SQL) to analyse a clinical database, extracting data on patients treated with clozapine to support future pharmacokinetic modelling. In addition, I explored how clozapine dissolves in the stomach, focusing on how proton pump inhibitors (PPIs), by affecting gastric pH, might alter clozapine absorption. This involved participating in laboratory experiments to generate a solubility curve and conducting a thorough literature review. I then drafted an article synthesising these findings and began developing my final poster presentation.