Elliot Noble

• MBBS
• Exploring the activity of deiodinase 2 in the human prostate stem cell niche & the implications for prostate carcinogenesis

Prostate cancer is the most common cancer among men and is often not detected until late stages. There is an urgent need for new forms of treatment, and therefore, a better understanding of the processes leading to the development of prostate cancer and its progression. It has recently been discovered that a small group of cells, known as prostate stem cells, are largely responsible for the control of the prostate gland. Mutations, or changes in the DNA of these cells, can result in uncontrolled multiplication of cells and can ultimately lead to cancer. My project involved looking at these stem cells in more detail, to better understand the signalling pathways that are involved in keeping the cells under control and preventing uncontrolled multiplication. 

Funding source: Newcastle University

Project supervisor: Dr Rakesh Heer