Nannapat Siraboriphantakul

• BDS Dentistry
• The Role of Voltage-gated Potassium Channels (Kv7) and Ca2+ sensing receptors in Persistent Orofacial Pain

Persistent neuropathic orofacial pain (POFP) is a condition where neurons (nerve cells) in the mouth have heightened excitability and as a consequence, uncontrollably transmit pain signals. The increase in excitability of these neurons is often due to imbalances between chemicals (potassium and calcium) that enters and exits the neuron through specific channels. These imbalances may cause death of the neurons and tissues nearby which may worsen the condition. Current treatment for POFP is inefficient because the mechanism behind POFP is not fully understood. In this project, we would like to test if by increasing the movement of potassium out of the neuron whilst simultaneously decreasing the neuron’s sensitivity to calcium we can decrease the hyperexcitability of the nerves and help restore their normal function thereby helping decrease pain. We will do this by using cell models that are in standard supply and testing them in different solutions.

Funding source: Newcastle University

Supervisor: Dr Vsevolod Telezhkin