David Olowookere

• Mpharm Pharmacy
• The identification and synthesis of novel allosteric integrase inhibitors

Studies have elucidated the basic importance of integrase in the replicative cycle of HIV; integration of viral DNA into host DNA results in permanent infection. Without treatment, progression to AIDS is inevitable. The purpose of this research is to develop new integrase inhibitors, that can both disrupt its core function (integration of viral DNA into human DNA) and its ancillary function in viral maturation; this is the process whereby new viral particles are assembled ready to infect health cells.

Funding source: Newcastle University

Supervisor: Dr Mark Ashton