2018 participants
Cezar Nicolae Barbu
My project is based on a protein complex called NF-kB. Specifically, it involves the role of the less-studied non-canonical NF-kB pathway in GBM (glioblastoma multiforme), a type of brain cancer. The non-canonocal NF-kB pathway is activated by a protein called IKK-alpha, which is activated by NIK (NF-kB inducing kinase). Studies have identified mechanisms by which the non-canonical NF-kB pathway can promote growth and proliferation of GBM. Prof. Perkins’ collaborators have recently produced a series of novel drugs, NIK and IKK-alpha inhibitors, that have therapeutic potential for the treatment of cancer. The aim of this project will be to investigate the effect of these drugs on GBM cell lines. Properties such as invasiveness and proliferation will be analysed to assess their therapeutic potential alone, as well as in combination with other already established drugs.
Funding source: Newcastle University
Supervisor: Prof Neil Perkins