Timothy Porter

• BSc (Hons) Biomedical Genetics
• Creation of an opsin library for neurophysiology research

Controlling Abnormal Network Dynamics using Optogenetics (CANDO) is a cross-disciplinary project that aims to create a brain implant with the ability to regulate neuronal activity for use in the treatment of focal epilepsy.

Our lab is interested in creating a library of opsin genes, derived from algae that can be integrated into neurons using gene therapy. This causes the cells to produce ion channels which open when exposed to specific wavelengths of visible light, regulating their activity by exciting or inhibiting them.

This project aims to create a library of opsins with different characteristics, such as sensitivity to different wavelengths.

Project Supervisor: Dr Elizabeth Stoll, Institute of Neuroscience

Funding Source: Newcastle University