Sin Yin Kee

• Bsc (Hons) Biomedical Sciences
• Assessing the contribution of KMT5A phosphorylation to AR signalling in prostate cancer

Current therapies for castrate resistant prostate cancer offer minimal clinical benefit. The androgen receptor (AR) is a cellular component or protein which is thought to be important in this disease so understanding how it is regulated will help to identify how it can be targeted therapeutically. KMT5A is another protein which can influence the AR and therefore may provide such a target. This project will determine how a modified and more robust KMT5A can affect the activity of the AR to evaluate KMT5A as a therapeutic target and/or biomarker for aggressive disease.

Funding source: Wellcome Trust