Jack Eklid

• Bsc (Hons) Physiological Sciences
• Quantification of Cox4 in the prefrontal cortex in post-stroke, vascular, and other ageing related dementias

Using Image Pro software I analysed post mortem tissue samples from Layers III and V of the dorsolateral prefrontal cortex (dlPFC) stained with anti-Cytochrome c Oxidase subunit IV (Cox4) antibody from post stroke demented and non-demented, vascular demented, Alzheimer’s disease and mixed demented cases and compared the data to control cases. I used two quantitative measures: Per Area and Integrated Optical density. I completed non parametric statistical analysis on the data obtained using SPSS. I was able to show significant changes in Cox4 in demented brains and found correlations with indicators of executive dysfunction. Neuropsychometric measures were available for post stroke cases through the Cognitive Function After Stroke (CogFAST) study.

Funding Source: Newcastle University