Hannah Fuller

• Bsc (Hons) Biochemistry
• The effects of Skp2 N-terminal post-translational modification on its interactions with CDK2/cyclin A

A cell completes one round of the cell cycle when it grows and divides to generate two daughter cells. A family of proteins called cyclin-dependent kinases (CDKs) control this process. A protein called Skp2 is an important regulator of the cell cycle because it controls the levels of another protein called p27 that inhibits CDK2 activity. The aim of this project is to understand one of the ways in which the levels of Skp2 in a cell are regulated. Understanding how this regulation works might provide an opportunity to develop new anti-cancer drugs.

Funding Source: Newcastle University