Robert Bloxham

• MSci Biomedical Sciences
• The effects of SkP2 N-terminal phosphorylation on its interactions with CDK2/cylin A and CDH1

A cell completes one round of the cell cycle when it grows and divides to generate two daughter cells. A family of proteins called cyclin-dependant kinases (CDK’s) control this process. A protein called Skp2 is an important regulator of the cell cycle because it controls the levels of another protein called p27 that inhibits CDK2 activity. The aim of this project is to understand one of the ways in which the levels of Skp2 in a cell are regulated. Understanding how this regulation works might provide an opportunity to develop anti-cancer drugs.

Funding source: Newcastle University