2012 Participants
Stephanie Matthews
Prostate cancer sometimes develops due to errors within the androgen signalling cascade. KDM4B is a demethylase enzyme that can remove a trimethyl group from histone 3 at lysine 9. It can interact and potentially act as a co-activator for the androgen receptor (AR) that interacts with nuclear elements which plays a role in development of the prostate. Hence the aim of this study was to investigate whether interaction between AR and KDM4B is regulated by AR-methylation. It was determined that AR methylation was not required for KDM4B-AR interaction, but the mechanisms of how this interaction occurs remain unknown.
Funding source: Wellcome Trust