Emma Curry

• BSc Biomedical Sciences
• Does the Cdc25A C-terminal tail selectively regulate the activity of CDK/cyclin complexes?

The growth and division of cells is strictly controlled by a series of enzymes that include the cyclin dependent protein kinases (CDKs). These enzymes are switched off and on in an orderly sequence to ensure that cell division starts and stops at the required time. Cdc25A is an enzyme that switches on CDKs and whose activity is elevated in certain cancer types. This project aims to use biochemical and biophysical methods to understand the way in which a specific modification of the Cdc25A protein affects its ability to bind to and regulate CDK activity.

Funding source: Newcastle University