Amanda Dalby

• BSc (Hons) Human Genetics
• Next-generation sequencing in families with inherited cardiac arrhythmias.

My research involved using a modern technology called ‘next-generation sequencing’, which is transforming the way in which genetic mutations are detected. Mutations in genes can cause several inherited conditions governing heart rhythm. Using next-generation sequencing, my project investigated a family in which sudden fatal or life-threatening disturbances of heart rhythm have occurred, due to unknown genetic causes.  I used this new technology to examine all the genes in the human genome in affected family members, to search for new mutations that may be responsible for their condition.

Funding Source: Newcastle University