DNA and Biospecimens

DNA

The active repositories of native and cell line DNA, and the cell-lines themselves are stored in freezers and cryostores in the ALSPAC laboratories, University of Bristol under the management of Dr Sue Ring. The cell lines are backed up by an inactive archive (not accessed to supply users) held at the European Collection of Cell Culture within the Health Protection Agency Centre for Emergency Preparedness at Porton Down, Wiltshire.  Access to all DNA samples is overseen by the METADAC committee (see details below).

Biospecimens

This comprises biomedical samples (whole blood, plasma and saliva) collected in the 2003 biomedical survey. All access is overseen by the METADAC committee.

Biochemical data already available from the biosamples includes the following markers:

  • C reactive protein
  • Fibrinogen
  • HbA1c
  • HDL cholesterol
  • IGF Specific IgE
  • T cholesterol
  • Total IgE
  • Tissue Plasminogen Activator
  • Triglycerides
  • Von Willebrand Factor
  • Serum 25-Hydroxyvitamin D

Goverance and Access

DNA and biospecimens can be accessed by application to METADAC on the 1958BC application form.

  • Guidance is available in the 1958 documentation, from CLS or from the METADAC Secretariat.
  • There is currently an open call for use of the biospecimen resource.
  • You should check the example MTA with your legal team in advance, as no samples will be issued unless they authorise your institution to sign this.
  • Samples (e.g. DNA plates) are prepared by University of Bristol and shipped to researchers.
  • All applications are reported to the CLS Strategic Advisory Board ‚Äčand successful applications are listed on the METADAC web-page.