Header/filter description

Author is the lead author of the dataset.

Cell line is the type of cell line used in the experiments.

Control/Control type is the sample used as a control against the experimental sample.

Control gene down specifies whether any genes were downregulated in control samples.

Control gene up specifies whether any genes were upregulated in control samples. Control PD is the number of population doublings (PDs) a control sample has gone through if specified.

Disease indicates whether cells used were diseased cells or not.

DOI is the DOI link to any studies associated with the dataset it is attached to.

Gene is the gene name of interest in that specific comparison.

Immortal line denotes whether the cell line is immortalised or not (typically done via hTERT overexpression).

LogFC is the Log fold change (LogFC) for the comparison in that specific line.

Median LogFC is the median LogFC of all sample comparisons for a gene.

Median P-value is the median P-value of all sample comparisons for a gene.

Numeric time (days) is the timepoint (in days) at which the sample was extracted and analysed.

Organ is the cell line organ origin – either skin or lung.

PD is the number of population doublings an experimental sample has gone through if specified.

P-value is the p-value for the comparison in that specific line.

Senescence subtype is the specific mode of induction of senescence, such as IR or etoposide for DDIS.

Senescence type is the type of senescence induced in experimental samples. When NA this may be due to the comparison been a control with treatment versus control with no treatment (for example, proliferating cells with siRNA treatment versus proliferating cells with no siRNA treatment).

Sen v NonSen only when selected as yes, means only data which compares senescent cells to non-senescent control cells (proliferating, quiescent or immortalised) will be presented.

Significant comparisons is the number of comparisons drawn from all datasets in which the Median P-value is <0.05.

Study identifier is the specific accession code associated with the dataset.

Targeted gene down specifies whether any genes were downregulated in experimental samples.

Targeted gene up specifies whether any genes were upregulated in experimental samples.

Treatment specifies whether the cells have undergone any other type of treatment besides senescence induction (for example treatment with an additional drug or knockdown technology).

Timepoints denote the time at which experimental samples were analysed.

Total comparisons is the total number of comparisons drawn from all datasets.

DDIS… DNA damage induced senescence

OIS… oncogene induced senescence

REP… replicative senescence

OSKM… OCT4, SOX2, KLF4 and MYC induced senescence

NIS… Notch induced senescence

RNIS… RAS and Notch induced senescence

NBIS… nuclear barrier induced senescence

CR… chromatin remodelling induced senescence

dNTP… senescence induced through depletion of deoxyribonucleotide triphosphates

Ribomature… senescence induced through ribosomal disruption

IR… irradiation