The AuToDeCRA project is developing a new type of medicine that uses a person's own white blood cells to calm the overactive immune system seen in Rheumatoid Arthritis (RA). The cells used in this experimental medicine are called tolerogenic dendritic cells or TolDC.

We have already carried out a study that showed that we can make TolDCs using white blood cell samples from patients with RA and that the treatment is safe to give to patients with active arthritis. However, we do not know the best place to introduce this medicine into the body.

The AuToDeCRA-2 study will compare a range of different administration routes and doses of our experimental medicine to see if how we administer the medicine impacts how well it works.