The 5 Year Plan

2025

Akinmolayan A, Papacosta AO, Lennon LT, Ellins EA, Halcox JPJ, Whincup PH, Wannamethee SG. Carotid Intima-Media Thickness, Carotid Distensibility, and Incident Heart Failure in Older Men: The British Regional Heart Study. J Am Heart Assoc. 2025;14(7):e037167.

Cai Z, Papacosta AO, Lennon LT, Whincup PH, Wannamethee SG, Simonsick EM, et al. Associations of social engagement and loneliness with the progression and reversal of frailty: longitudinal investigations of 2 prospective cohorts from the UK and the USA. Am J Epidemiol. 2025;194(4):984-93.

Chawla M, Papacosta O, Lennon L, Ahmed A, Whincup P, Wannamethee SG. Association of ideal cardiovascular health and Life's Simple 7 metrics with incident heart failure among older men: the British Regional Heart Study. Eur J Prev Cardiol. 2025.

Ganbavale SG, Cai Z, Mathers JC, Papacosta O, Lennon L, Whincup PH, et al. Association between poor oral health and deterioration of appetite in older age: results from longitudinal analyses of two prospective cohorts from the UK and USA. BMJ Open. 2025;15(2):e083973.

Global Cardiovascular Risk C, Magnussen C, Alegre-Diaz J, Al-Nasser LA, Amouyel P, Aviles-Santa L, et al. Global Effect of Cardiovascular Risk Factors on Lifetime Estimates. N Engl J Med. 2025.

Shah ASV, Keene SJ, Pennells L, Kaptoge S, Kimenai DM, Walker M, et al. Cardiac Troponins and Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis. J Am Coll Cardiol. 2025;85(14):1471-84.

2024

Cai Z, Papacosta AO, Lennon LT, Whincup PH, Wannamethee SG, Simonsick EM, et al. Associations of social engagement, and loneliness with the progression and reversal of frailty: longitudinal investigations of two prospective cohorts from the UK and the USA. Am J Epidemiol. 2024. doi: 10.1093/aje/kwae221

Ganbavale SG, Papachristou E, Mathers JC, Papacosta AO, Lennon LT, Whincup PH, et al. Neighborhood Deprivation and Changes in Oral Health in Older Age: A Longitudinal Population-Based Study. J Dent Res. 2024;103(4):434-41.

Wang QY, Schmidt AF, Lennon LT, Papacosta O, Whincup PH, Wannamethee G. Association of Life's Simple 7 lifestyle metric with cardiometabolic disease-free life expectancy in older British men. Commun Med-London. 2024;4(1).

Wannamethee SG. Napping and Obesity in Adults - What do we Know? Curr Diab Rep. 2024;24(11):237-43.

NCD Risk Factor Collaboration (NCD-RisC). Phelps NH et al Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet. 2024;403(10431):1027-1050. doi: 10.1016/S0140-6736(23)02750-2.

NCD Risk Factor Collaboration (NCD-RisC). Zhou B et al. General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants. The Lancet, 2024;404(10455):851–863.

NCD Risk Factor Collaboration (NCD-RisC). Zhou et al. Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants. Lancet. 2024 Nov 23;404(10467):2077-2093.

2023

Ahmed A, Ambler G, Pinto Pereira SM, Lennon L, Papacosta O, Whincup P, et al. Stroke risk in older British men: Comparing performance of stroke-specific and composite-CVD risk prediction tools. Prev Med Rep. 2023;31:102098.

Bush KJ, Papacosta AO, Lennon LT, Rankin J, Whincup PH, Wannamethee SG, et al. Influence of neighborhood-level socioeconomic deprivation and individual socioeconomic position on risk of developing type 2 diabetes in older men: a longitudinal analysis in the British Regional Heart Study cohort. BMJ Open Diabetes Res Care. 2023;11(5).

Chen A, Lennon L, Papacosta O, Wannamethee SG. Association of night-time sleep duration and daytime napping with all-cause and cause-specific mortality in older British men: from the British Regional Heart Study. Sleep Medicine. 2023;109:32-9.

Global Cardiovascular Risk C, Magnussen C, Ojeda FM, Leong DP, Alegre-Diaz J, Amouyel P, et al. Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. N Engl J Med. 2023;389(14):1273-85.

Kaptoge S, Sun L, Walker M, Spackman S, Pennells L, Seshasai SRK, et al. Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation. Lancet Diabetes Endo. 2023;11(10):731-42.

Kimble R, McLellan G, Lennon LT, Papacosta AO, Mathers JC, Wannamethee SG, et al. Cohort Profile Update: The British Regional Heart Study 1978-2018: 40 years of follow-up of older British men. Int J Epidemiol. 2023;52(3):e187-e94.

Kimble R, Papacosta AO, Lennon LT, Whincup PH, Weyant RJ, Mathers JC, et al. The Relationships of Dentition, Use of Dental Prothesis and Oral Health Problems with Frailty, Disability and Diet Quality: Results from Population-Based Studies of Older Adults from the UK and USA. J Nutr Health Aging. 2023;27(8):663-72.

Kimble R, Papacosta AO, Lennon LT, Whincup PH, Weyant RJ, Mathers JC, et al. The Relationship of Oral Health with Progression of Physical Frailty among Older Adults: A Longitudinal Study Composed of Two Cohorts of Older Adults from the United Kingdom and United States. J Am Med Dir Assoc. 2023;24(4):468-74 e3.

Mitchell JJ, Hamer M, Blodgett JM, Wannamethee GS, Jefferis BJ. Associations between sporting physical activity and cognition in mid and later-life: Evidence from two cohorts. Scand J Med Sci Sports. 2023;33(8):1570-5.

Paluch AE, Bajpai S, Ballin M, Bassett DR, Buford TW, Carnethon MR, Chernofsky A... Steps for Health Collaborative. Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis.. Circulation, 2023;147 (2):122-131

Schmidt AF, Joshi R, Gordillo-Maranon M, Drenos F, Charoen P, Giambartolomei C, et al. Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes. Commun Med-London. 2023;3(1).

Wang Q, Schmidt AF, Lennon LT, Papacosta O, Whincup PH, Wannamethee SG. Prospective associations between diet quality, dietary components, and risk of cardiometabolic multimorbidity in older British men. Eur J Nutr. 2023;62(7):2793-804.

Wannamethee SG, Atkins JL. Sarcopenic Obesity and Cardiometabolic Health and Mortality in Older Adults: a Growing Health Concern in an Ageing Population. Curr Diab Rep. 2023.

Zhou B, Sheffer KE, Bennett JE, Gregg EW, Danaei G, Singleton RK, et al. Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c. Nat Med. 2023.

2022

Coyte A, Perry R, Papacosta AO, Lennon L, Whincup PH, Wannamethee SG, et al. Social relationships and the risk of incident heart failure: results from a prospective population-based study of older men. Eur Heart J Open. 2022;2(1):oeab045.

Gaziano L, Sun L, Arnold M, Bell S, Cho K, Kaptoge SK et al. Emerging Risk Factors Collaboration/EPIC-CVD/Million Veteran Program. Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses. Circulation. 2022 Nov 15;146(20):1507-1517. doi: 10.1161/CIRCULATIONAHA.122.060700. Epub 2022 Oct 31. PMID: 36314129; PMCID: PMC9662821.

Kimble R, McLellan G, Lennon LT, Papacosta AO, Mathers JC, Wannamethee SG, Whincup PH, Ramsay SE. Cohort Profile Update: The British Regional Heart Study 1978-2018: 40 years of follow-up of older British men. Int J Epidemiol. 2022 Jun 3:dyac122. doi: 10.1093/ije/dyac122. Epub ahead of print. PMID: 35656703.

Kimble R, Papacosta AO, Lennon LT, Whincup PH, Weyant RJ, Mathers JC, Wannamethee SG, Ramsay SE. The Relationship of Oral Health With Progression of Physical Frailty Among Older Adults: A Longitudinal Study Composed of Two Cohorts of Older Adults From the United Kingdom and United States. J Am Med Dir Assoc. 2022 Dec 27:S1525-8610(22)00919-7. doi: 10.1016/j.jamda.2022.11.022. Epub ahead of print. PMID: 36584971.

Kotronia E, Brown H, Papacosta O, Lennon LT, Weyant RJ, Whincup PH, et al. Oral health problems and risk of incident disability in two studies of older adults in the United Kingdom and the United States. Journal of the American Geriatrics Society. 2022.

McKechnie DGJ, Patel M, Papacosta AO, Lennon LT, Ellins EA, Halcox JPJ, et al. Associations between inflammation, coagulation, cardiac strain and injury, and subclinical vascular disease with frailty in older men: a cross-sectional study. BMC Geriatr. 2022;22(1):405.

Paluch AE, Bajpai S, Bassett DR, Carnethon MR, Ekelund U, Evenson KR, et al. Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts. Lancet Public Health. 2022;7(3):e219-e28.

Schutte R, Smith L, Wannamethee G. Alcohol-The myth of cardiovascular protection. Clinical Nutrition. 2022;41(2):348-55.

Tarp J, Fagerland MW, Dalene KE, Johannessen JS, Hansen BH, Jefferis BJ, et al. Device-measured physical activity, adiposity and mortality: a harmonised meta-analysis of eight prospective cohort studies. Br J Sports Med. 2022;56(13):725-32.

Wannamethee SG. Frailty and increased risk of cardiovascular disease: are we at a crossroad to include frailty in cardiovascular risk assessment in older adults? Eur Heart J. 2022;43(8):827-9.

Wannamethee SG, Papacosta O, Lennon L, Whincup PH, Rumley A, Lowe GDO. Haematological variables and risk of future venous thromboembolism in the British Regional Heart Study on men. Combined D-dimer and APTT as a predictive test for thromboembolism? Br J Haematol. 2022;198(3):587-94.

2021

Ahluwalia TS, Prins BP, Abdollahi M, et al. Genome-wide association study of circulating interleukin 6 levels identifies novel loci. Hum Mol Genet 2021; 30(5): 393-409. doi: 10.1093/hmg/ddab023. https://www.ncbi.nlm.nih.gov/pubmed/33517400

Gilani A, De Caterina R, Papacosta O, Lennon LT, Whincup PH, Wannamethee SG. Excessive Orthostatic Changes in Blood Pressure Are Associated With Incident Heart Failure in Older Men: A Prospective Analysis From the BRHS. Hypertension 2021; 77(5): 1481-9. doi: 10.1161/HYPERTENSIONAHA.120.15817. Epub 2021 Mar 15.

Gilani A, Ramsay SE, Welsh P, et al. Vitamin D deficiency is associated with orthostatic hypotension in older men: a cross-sectional analysis from the British Regional Heart Study. Age Ageing 2021; 50(1): 198-204. doi: 10.1093/ageing/afaa146.

Gordillo-Maranon M, Zwierzyna M, Charoen P, et al. Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics. Nat Commun 2021; 12(1): 6120. doi: 10.1038/s41467-021-25731-z.

Joshi R, Wannamethee G, Engmann J, et al. Establishing reference intervals for triglyceride-containing lipoprotein subfraction metabolites measured using nuclear magnetic resonance spectroscopy in a UK population. Ann Clin Biochem 2021; 58(1): 47-53. doi: 10.1177/0004563220961753. Epub 2020 Oct 21.

Kotronia E, Brown H, Papacosta AO, et al. Oral health and all-cause, cardiovascular disease, and respiratory mortality in older people in the UK and USA. Sci Rep 2021; 11(1): 16452. doi: 10.1038/s41598-021-95865-z.

Kotronia E, Brown H, Papacosta AO, et al. Poor oral health and the association with diet quality and intake in older people in two studies in the UK and USA. Br J Nutr 2021; 126(1): 118-30. doi: 10.1017/S0007114521000180. Epub 2021 Jan 20. (Kotronia E, Brown H, Olia Papacosta A, et al. Poor oral health and the association with diet quality and intake in older people in two studies in the UK and USA - CORRIGENDUM. Br J Nutr 2021; 126(1): 160. doi: 10.1017/S0007114521000878. Epub 2021 Mar 22.)

Kotronia E, Wannamethee SG, Papacosta AO, et al. Poor Oral Health and Inflammatory, Hemostatic, and Cardiac Biomarkers in Older Age: Results From Two Studies in the UK and USA. J Gerontol A Biol Sci Med Sci 2021; 76(2): 346-51. doi: 10.1093/gerona/glaa096

McKechnie DG, Papacosta AO, Lennon LT, Ramsay SE, Whincup PH, Wannamethee SG. Frailty and incident heart failure in older men: the British Regional Heart Study. Open Heart 2021; 8(1). doi: 10.1136/openhrt-2021-001571

McKechnie DG, Papacosta AO, Lennon LT, Welsh P, Whincup PH, Wannamethee SG. Inflammatory markers and incident heart failure in older men: the role of NT-proBNP. Biomark Med 2021; 15(6): 413-25. doi: 10.2217/bmm-2020-0669. Epub 2021 Mar 12.

McKechnie DGJ, Papacosta AO, Lennon LT, et al. Subclinical cardiovascular disease and risk of incident frailty: The British Regional Heart Study. Exp Gerontol 2021; 154: 111522. doi: 10.1016/j.exger.2021.111522. Epub 2021 Aug 21.

McKechnie DGJ, Papacosta AO, Lennon LT, Ramsay SE, Whincup PH, Wannamethee SG. Associations between inflammation, cardiovascular biomarkers and incident frailty: the British Regional Heart Study. Age Ageing 2021; 50(6): 1979-87. doi: 10.1093/ageing/afab143

Schmidt AF, Hunt NB, Gordillo-Maranon M, et al. Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease. Nat Commun 2021; 12(1): 5640. doi: 10.1038/s41467-021-25703-3

Wannamethee SG, Papacosta O, Lennon L, Hingorani A, Whincup P. Adult height and incidence of atrial fibrillation and heart failure in older men: The British Regional Heart Study. Int J Cardiol Heart Vasc 2021; 35: 100835. doi: 10.1016/j.ijcha.2021.100835. eCollection 2021 Aug.

2020

Aggio D, Papachristou E, Papacosta O, Lennon LT, Ash S, Whincup P, Wannamethee SG, Jefferis BJ.Trajectories of physical activity from midlife to old age and associations with subsequent cardiovascular disease and all-cause mortality. J Epidemiol Community Health. 2020 Feb;74(2):130-136. doi: 10.1136/jech-2019-212706. Epub 2019 Nov 8. PMID: 31704805

Ahmed A, Pinto Pereira SM, Lennon L, Papacosta O, Whincup P, Wannamethee G. Cardiovascular Health and Stroke in Older British Men: Prospective Findings From the British Regional Heart Study. Stroke. 2020;51(11):3286-94. DOI: 10.1161/STROKEAHA.120.030546

Borges MC, Schmidt AF, Jefferis B, Wannamethee SG, Lawlor DA, Kivimaki M, et al. Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta-Analysis in Up to 16 126 Participants. J Am Heart Assoc. 2020;9(5):e013131.PMCID: PMC7335585 DOI: 10.1161/JAHA.119.013131

Brunner FJ, Waldeyer C, Ojeda F, Salomaa V, Kee F, Sans S, Thorand B, Giampaoli S, Brambilla P, Tunstall-Pedoe H, Moitry M, Iacoviello L, Veronesi G, Grassi G, Mathiesen EB, Söderberg S, Linneberg A, Brenner H, Amouyel P, Ferrières J, Tamosiunas A, Nikitin YP, Drygas W, Melander O, Jöckel KH, Leistner DM, Shaw JE, Panagiotakos DB, Simons LA, Kavousi M, Vasan RS, Dullaart RPF, Wannamethee SG, Risérus U, Shea S, de Lemos JA, Omland T, Kuulasmaa K, Landmesser U, Blankenberg S; Multinational Cardiovascular Risk Consortium. Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium. Lancet. 2019 Dec 14;394(10215):2173-2183. doi: 10.1016/S0140-6736(19)32519-X. Epub 2019 Dec 3. Erratum in: Lancet. 2019 Dec 6 Lancet. 2020 Jan 4;395(10217):32. PMID: 31810609

Ekelund U, Tarp J, Fagerland MW, Johannessen JS, Hansen BH, Jefferis BJ, et al. Joint associations of accelero-meter measured physical activity and sedentary time with all-cause mortality: a harmonised meta-analysis in more than 44 000 middle-aged and older individuals. Br J Sports Med. 2020;54(24):1499-506. PMCID: PMC7719907 DOI: 10.1136/bjsports-2020-103270

Gilani A, Ramsay S, Welsh P, Papacosta O, Lennon L, Whincup P, et al. Vitamin D deficiency is associated with increased risk of postural hypotension in older men: a cross-sectional analysis from The British Regional Heart Study. Br J Gen Pract. 2020;70(suppl 1). DOI: 10.3399/bjgp20X711209

Gilani A, Ramsay SE, Juraschek SP, Papacosta O, Lennon LT, Whincup PH, et al. Associations of the systolic and diastolic components of orthostatic hypotension with markers of cardiovascular risk in older men: A cross-sectional analysis from The British Regional Heart Study. J Clin Hypertens (Greenwich). 2020;22(10):1892-901. PMCID: PMC8029713 DOI: 10.1111/jch.13996

Joshi R, Wannamethee SG, Engmann J, Gaunt T, Lawlor DA, Price J, Papacosta O, Shah T, Tillin T, Chaturvedi N, Kivimaki M, Kuh D, Kumari M, Hughes AD, Casas JP, Humphries S, Hingorani AD, Schmidt AF. Triglyceride-containing lipoprotein sub-fractions and risk of coronary heart disease and stroke: A prospective analysis in 11,560 adults. Eur J Prev Cardiol. 2020 Jan 29:2047487319899621. doi: 10.1177/2047487319899621. [Epub ahead of print] PMID: 31996015

Liljas AEM, Walters K, de Oliveira C, Wannamethee SG, Ramsay SE, Carvalho LA. Self-Reported Sensory Impairments and Changes in Cognitive Performance: A Longitudinal 6-Year Follow-Up Study of English Community-Dwelling Adults Aged 50 Years. J Aging Health. 2020;32(5-6):243-51.PMCID: PMC7221867 DOI: 10.1177/0898264318815391

2019

Aggio D, Papachristou E, Papacosta O, et al. Twenty-Year Trajectories of Physical Activity Types from Midlife to Old Age. Med Sci Sports Exerc 2019; 51(3): 481-9.

Eng, J., Drabwell., Stevenson, F., King, M., Osborn, D., Pitman, A. (2019). Use of Alcohol and Unprescribed Drugs after Suicide Bereavement: Qualitative Study. Int J Environ Res Public Health 16, 4093. https://doi.org/10.3390/ijerph16214093

Jefferis BJ, Parsons TJ, Sartini C, et al. Does total volume of physical activity matter more than pattern for onset of CVD? A prospective cohort study of older British men. Int J Cardiol 2019; 278: 267-72.

Parsons TJ, Papachristou E, Atkins JL, et al. Physical frailty in older men: prospective associations with diet quality and patterns. Age Ageing 2019; 48(3): 355-60.

Rankin NJ, Burgess K, Weidt S, Wannamethee G, Sattar N, Welsh P. High-throughput quantification of carboxymethyl lysine in serum and plasma using high-resolution accurate mass Orbitrap mass spectrometry. Ann Clin Biochem 2019; 56(3): 397-407.

Welsh P, Papacosta O, Ramsay S, et al. High-Sensitivity Troponin T and Incident Heart Failure in Older Men: British Regional Heart Study. J Card Fail 2019; 25(4): 230-7.

Zonoozi S, Ramsay SE, Papacosta O, et al. Chronic kidney disease, cardiovascular risk markers and total mortality in older men: cystatin C versus creatinine. J Epidemiol Community Health 2019; 73(7): 645-51.

2018

Aggio D, Papachristou E, Papacosta O, Lennon L, Ash S, Whincup PH, Wannamethee SG, Jefferis1 BJ. Association Between Twenty-year Trajectories Of Physical Activity From Midlife To Old Age And Biomarkers of CVD: A 20-Year Longitudinal Study Of British Men. American J Epidemiology 2018 Nov 1:187:2315-2323

Aggio D, Papachristou E, Papacosta O, Lennon LT, Ash S, Whincup PH, et al. Trajectories of self-reported physical activity and predictors during the transition to old age: a 20-year cohort study of British men. The International Journal of Behavioral Nutrition and Physical Activity 2018;15(1):14 Epub 2018/02/09

Aggio D, Papacosta O, Lennon LT, Ash S, Whincup PH, Goya Wannamethee S, Jefferis BJ. Tracking of sport and exercise types from midlife to old age: a 20-year cohort study of British men. Eur Rev Aging Phys Act. 2018 Dec 7;15:16.

Hawkesworth S, Silverwood RJ, Armstrong B, Pliakas T, Nanchalal K, Jefferis BJ, et al. Investigating associations between the built environment and physical activity among older people in 20 UK towns. Journal of Epidemiology and Community Health. 2018;72(2):121-31. Epub 2017/11/28

Jefferis BJ, Parsons TJ, Sartini C, Ash S, Lennon LT, Papacosta O, et al. Objectively measured physical activity, sedentary behaviour and all-cause mortality in older men: does volume of activity matter more than pattern of accumulation? British Journal of Sports Medicine. 2018. Epub 2018/02/15

Parsons TJ, Sartini C, Welsh P, Sattar N, Ash S, Lennon LT, et al. Objectively measured physical activity and cardiac biomarkers: A cross sectional population based study in older men International Journal of Cardiology. 2018;254:322-7. Epub 2018/02/07

Parsons TJ, Papachristou E , Atkins JL, Papacosta O, Ash S, Lennon L, Whincup PH, Ramsay SE, Wannamethee SG. Healthier diet quality and dietary patterns are associated with lower risk of mobility limitation in older men. European Journal of Nutrition 2018; Epub Jul 23

Ramsay SE, Papachristou E, Watt RG, Lennon LT, Papacosta AO, Whincup PH, Wannamethee SG. Socioeconomic disadvantage across the life-course and oral health in older age: findings from a longitudinal study of older British men. J Public Health (Oxf). 2018 Apr 19. doi: 10.1093/pubmed/fdy068. [Epub ahead of print]

Sartini C, Tammes P, Hay AD, Preston I, Lasserson D, Whincup PH, et al. Can we identify older people most vulnerable to living in cold homes during winter? Annals of Epidemiology. 2018;28(1):1-7 e3 Epub 2018/02/10

Wannamethee SG, Papacosta O, Lennon L, Whincup PH. Serum magnesium and risk of incident heart failure in older men: The British Regional Heart Study. Eur J Epidemiol. 2018 Apr 17. doi: 10.1007/s10654-018-0388-6. [Epub ahead of print]

Wannamethee SG, Jefferis BJ, Lennon L, Papacosta O, Whincup PH, Hingorani AD. Serum Conjugated Linoleic Acid and Risk of Incident Heart Failure in Older Men: The British Regional Heart Study. Journal of the American Heart Association 2018;7(1).

Wannamethee SG, Papacosta O, Lennon L, Whincup PH. Serum uric acid as a potential marker for heart failure risk in men on antihypertensive treatment: The British Regional Heart Study. International Journal of Cardiology. 2018;252:187-92.

Welsh P, Papacosta O, Ramsay S, Whincup P, McMurray J, WannametheeG, Sattar N. High-Sensitivity Troponin T and Incident Heart Failure in Older Men: British Regional Heart Study. J Card Fail. 2018 Aug 11.

NCD Risk Factor Collaboration (NCD-RisC) Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants. Int J Epidemiol. 2018 Mar 19. doi: 10.1093/ije/dyy016. [Epub ahead of print]

Prospective Studies Collaboration and Asia Pacific Cohort Studies Collaboration Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980 793 adults from 68 prospective studies. Lancet Diabetes Endocrinol. 2018 Jul;6(7):538-546. doi: 10.1016/S2213-8587(18)30079-2. Epub 2018 May 8.

Franceschini N, Giambartolomei C, de Vries PS et al. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018 Dec 3;9(1):5141.

2017

Aggio D, Papacosta O, Lennon L, Whincup P, Wannamethee G, Jefferis BJ. Association between physical activity levels in mid-life with physical activity in old age: a 20-year tracking study in a prospective cohort. BMJ Open. 2017;7(8):e017378.

Beaney KE, Smith AJP, Folkersen L, Palmen J, Wannamethee SG, Jefferis BJ, et al. Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22. Disease markers. 2017;2017:1096916.

Ellins EA, Smith KE, Lennon LT, Papacosta O, Wannamethee SG, Whincup PH, et al. Arterial pathophysiology and comparison of two devices for pulse wave velocity assessment in elderly men: the British regional heart study. Open Heart. 2017;4(2):e000645.

Fairoozy RH, Cooper J, White J, Giambartolomei C, Folkersen L, Wannamethee SG, et al. Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene. Atherosclerosis. 2017;261:60-8.

Hawkesworth S, Silverwood RJ, Armstrong B, Pliakas T, Nanchahal K, Sartini C, et al. Investigating the importance of the local food environment for fruit and vegetable intake in older men and women in 20 UK towns: a cross-sectional analysis of two national cohorts using novel methods. The International Journal of Behavioral Nutrition and Physical Activity. 2017;14(1):128.

Liljas AEM, Carvalho LA, Papachristou E, De Oliveira C, Wannamethee SG, Ramsay SE, et al. Self-reported vision impairment and incident prefrailty and frailty in English community-dwelling older adults: findings from a 4-year follow-up study. Journal of Epidemiology and Community Health. 2017;71(11):1053-8. Epub 2017/08/12

Liljas AEM, Carvalho LA, Papachristou E, Oliveira C, Wannamethee SG, Ramsay SE, et al. Self-Reported Hearing Impairment and Incident Frailty in English Community-Dwelling Older Adults: A 4-Year Follow-Up Study. Journal of the American Geriatrics Society. 2017;65(5):958-65. Epub 2016/12/20

Papachristou E, Wannamethee SG, Lennon LT, Papacosta O, Whincup PH, Iliffe S, et al. Ability of Self-Reported Frailty Components to Predict Incident Disability, Falls, and All-Cause Mortality: Results From a Population-Based Study of Older British Men. Journal of the American Medical Directors Association. 2017;18(2):152-7.

Parsons TJ, Sartini C, Ash S, Lennon LT, Wannamethee SG, Lee IM, et al. Objectively measured physical activity and kidney function in older men; a cross-sectional population-based study Age and Ageing. 2017;46(6):1010-4

Parsons TJ, Sartini C, Welsh P, Sattar N, Ash S, Lennon LT, et al. Physical Activity, Sedentary Behavior, and Inflammatory and Hemostatic Markers in Men. Medicine and Science in Sports and Exercise. 2017;49(3):459-65.

Ramsay SE, Papachristou E, Watt RG, Tsakos G, Lennon LT, Papacosta AO, et al. Influence of Poor Oral Health on Physical Frailty: A Population-Based Cohort Study of Older British Men Journal of the American Geriatrics Society. 2017.

Sartini C, Barry SJ, Whincup PH, Wannamethee SG, Lowe GD, Jefferis BJ, et al. Relationship between outdoor temperature and cardiovascular disease risk factors in older people. European journal of preventive cardiology. 2017;24(4):349-56.

Sartini C, Morris RW, Whincup PH, Wannamethee SG, Ash S, Lennon L, et al. Association of Maximum Temperature With Sedentary Time in Older British Men. Journal of Physical Activity & Health. 2017;14(4):265-9.

Sartini C, Whincup PH, Wannamethee SG et al. Associations of time of day with cardiovascular disease risk factors measured in older men: results from the British Regional Heart Study. BMJ Open 2017;7(11):e018264

Schutte R, Whincup PH, Papacosta O, Lennon LT, Macfarlane PW, Wannamethee G. Liver enzymes are not directly involved in atrial fibrillation: a prospective cohort study. European Journal of Clinical Investigation. 2017;47(8):583-90

Wannamethee SG, Welsh P, Papacosta O, Ellins EA, Halcox JPJ, Whincup PH, et al. Circulating soluble receptor for advanced glycation end product: Cross-sectional associations with cardiac markers and subclinical vascular disease in older men with and without diabetes. Atherosclerosis. 2017;264:36-43 Epub 2017/08/02

Wannamethee SG, Whincup PH, Papacosta O, Lennon L, Lowe GD. Associations between blood coagulation markers, NT-proBNP and risk of incident heart failure in older men: The British Regional Heart Study. International Journal of Cardiology. 2017;230:567-71.

NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017 Dec 16;390(10113):2627-2642.

NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants. Lancet. 2017 Jan 7;389(10064):37-55.

2016

Aggio DA, Sartini C, Papacosta O, Lennon LT, Ash S, Whincup PH, et al. Cross-sectional associations of objectively measured physical activity and sedentary time with sarcopenia and sarcopenic obesity in older men. Preventive medicine. 2016;91:264-72. Epub 2016/08/31.

Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG. Dietary patterns and the risk of CVD and all-cause mortality in older British men. The British journal of nutrition. 2016;116(7):1246-55. Epub 2016/09/14.

Beaney KE, Cooper JA, McLachlan S, Wannamethee SG, Jefferis BJ, Whincup P, et al. Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids. Cardiovascular diabetology. 2016;15(1):115. Epub 2016/08/24.

Charoen P, Nitsch D, Engmann J, Shah T, White J, Zabaneh D, et al. Mendelian Randomisation study of the influence of eGFR on coronary heart disease. Scientific reports. 2016;6:28514. Epub 2016/06/25.

Jefferis BJ, Parsons TJ, Sartini C, Ash S, Lennon LT, Wannamethee SG, et al. Does duration of physical activity bouts matter for adiposity and metabolic syndrome? A cross-sectional study of older British men. The international journal of behavioural nutrition and physical activity. 2016;13:36. Epub 2016/03/17.

Jefferis BJ, Sartini C, Ash S, Lennon LT, Wannamethee SG, Whincup PH. Validity of questionnaire-based assessment of sedentary behaviour and physical activity in a population-based cohort of older men; comparisons with objectively measured physical activity data. The international journal of behavioural nutrition and physical activity. 2016;13:14. Epub 2016/02/06.

Liljas AE, Carvalho LA, Papachristou E, Oliveira C, Wannamethee SG, Ramsay SE, et al. Self-Reported Hearing Impairment and Incident Frailty in English Community-Dwelling Older Adults: A 4-Year Follow-Up Study. Journal of the American Geriatrics Society. 2016. Epub 2016/12/20.

Liljas AE, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, et al. Hearing impairment and incident disability and all-cause mortality in older British community-dwelling men. Age and ageing. 2016;45(5):662-7. Epub 2016/05/06.

Liljas AE, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, et al. Sensory Impairments and Cardiovascular Disease Incidence and Mortality in Older British Community-Dwelling Men: A 10-Year Follow-Up Study. Journal of the American Geriatrics Society. 2016;64(2):442-4. Epub 2016/02/20.

Liljas AE, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, et al. Socio-demographic characteristics, lifestyle factors and burden of morbidity associated with self-reported hearing and vision impairments in older British community-dwelling men: a cross-sectional study. J Public Health (Oxf). 2016;38(2):e21-8. Epub 2015/07/17.

Morris RW, Cooper JA, Shah T, Wong A, Drenos F, Engmann J, et al. Marginal role for 53 common genetic variants in cardiovascular disease prediction. Heart. 2016;102(20):1640-7. Epub 2016/07/02.

Papachristou E, Ramsay SE, Papacosta O, Lennon LT, Iliffe S, Whincup PH, et al. The Test Your Memory cognitive screening tool: sociodemographic and cardiometabolic risk correlates in a population-based study of older British men. International journal of geriatric psychiatry. 2016;31(6):666-75. Epub 2015/10/23.

Parsons TJ, Sartini C, Ellins EA, Halcox JP, Smith KE, Ash S, et al. Objectively measured physical activity, sedentary time and subclinical vascular disease: Cross-sectional study in older British men. Preventive medicine. 2016;89:194-9. Epub 2016/06/05.

Parsons TJ, Sartini C, Ellins EA, Halcox JP, Smith KE, Ash S, et al. Objectively measured physical activity and sedentary behaviour and ankle brachial index: Cross-sectional and longitudinal associations in older men. Atherosclerosis. 2016;247:28-34. Epub 2016/02/09.

Sartini C, Barry SJ, Wannamethee SG, Whincup PH, Lennon L, Ford I, et al. Effect of cold spells and their modifiers on cardiovascular disease events: Evidence from two prospective studies. International journal of cardiology. 2016;218:275-83. Epub 2016/05/31.

Sartini C, Morris RW, Whincup PH, Wannamethee SG, Ash S, Lennon L, et al. Association of Maximum Temperature With Sedentary Time in Older British Men. Journal of physical activity & health. 2016:1-18. Epub 2016/12/30.

Wannamethee SG, Papacosta O, Lennon L, Whincup PH. Self-Reported Sleep Duration, Napping, and Incident Heart Failure: Prospective Associations in the British Regional Heart Study. Journal of the American Geriatrics Society. 2016;64(9):1845-50. Epub 2016/06/29.

Wannamethee SG, Shaper AG, Lennon L, Papacosta O, Whincup P. Mild hyponatremia, hypernatremia and incident cardiovascular disease and mortality in older men: A population-based cohort study. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2016;26(1):12-9. Epub 2015/08/25.

Wannamethee SG, Shaper AG, Papacosta O, Lennon L, Welsh P, Whincup PH. Lung function and airway obstruction: associations with circulating markers of cardiac function and incident heart failure in older men-the British Regional Heart Study. Thorax. 2016;71(6):526-34. Epub 2016/01/27.

Wannamethee SG, Welsh P, Lennon L, Papacosta O, Whincup PH, Sattar N. Copeptin and the risk of incident stroke, CHD and cardiovascular mortality in older men with and without diabetes: The British Regional Heart Study. Diabetologia. 2016;59(9):1904-12. Epub 2016/06/18.

Welsh P, Hart C, Papacosta O, Preiss D, McConnachie A, Murray H, et al. Prediction of Cardiovascular Disease Risk by Cardiac Biomarkers in 2 United Kingdom Cohort Studies: Does Utility Depend on Risk Thresholds For Treatment? Hypertension. 2016;67(2):309-15. Epub 2015/12/17.

White J, Sofat R, Hemani G, Shah T, Engmann J, Dale C, et al. Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis. The lancet Diabetes & endocrinology. 2016;4(4):327-36. Epub 2016/01/20.

2015

Atkins JL, Ramsay SE, Whincup PH, Morris RW, Lennon LT, Wannamethee SG. Diet quality in older age: the influence of childhood and adult socio-economic circumstances. The British journal of nutrition. 2015;113(9):1441-52. Epub 2015/04/02.

Herbert, A., Gilbert, R., Gonzalez-Izquierdo, A., Pitman, A., Li, L. (2015). Ten-year risks of death and emergency re-admission in adolescents hospitalised with violent, drug- or alcohol-related, or self-inflicted injury: a population-based analysis. PLoS MEdicine 12(12): e1001931. DOI: 10.1371/journal.pmed.1001931 (runner-up in UCL Excellence in Health Research Prize Dr Annie Herbert)

Jefferis BJ, Merom D, Sartini C, Wannamethee SG, Ash S, Lennon LT, et al. Physical Activity and Falls in Older Men: The Critical Role of Mobility Limitations. Medicine and science in sports and exercise. 2015;47(10):2119-28. Epub 2015/02/11.

Jefferis BJ, Sartini C, Ash S, Lennon LT, Wannamethee SG, Lee IM, et al. Trajectories of objectively measured physical activity in free-living older men. Medicine and science in sports and exercise. 2015;47(2):343-9. Epub 2014/07/06.

Jefferis BJ, Sartini C, Shiroma E, Whincup PH, Wannamethee SG, Lee IM. Duration and breaks in sedentary behaviour: accelerometer data from 1566 community-dwelling older men (British Regional Heart Study). British journal of sports medicine. 2015;49(24):1591-4. Epub 2014/09/19.

Lennon LT, Ramsay SE, Papacosta O, Shaper AG, Wannamethee SG, Whincup PH. Cohort Profile Update: The British Regional Heart Study 1978-2014: 35 years follow-up of cardiovascular disease and ageing. International journal of epidemiology. 2015;44(3):826-g. Epub 2015/08/02.

Linneberg A, Jacobsen RK, Skaaby T, Taylor AE, Fluharty ME, Jeppesen JL, et al. Effect of Smoking on Blood Pressure and Resting Heart Rate: A Mendelian Randomization Meta-Analysis in the CARTA Consortium. Circulation Cardiovascular genetics. 2015;8(6):832-41. Epub 2015/11/06.

Morris RW, Taylor AE, Fluharty ME, Bjorngaard JH, Asvold BO, Elvestad Gabrielsen M, et al. Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. BMJ open. 2015;5(8):e008808. Epub 2015/08/13.

Nuesch E, Dale C, Palmer TM, White J, Keating BJ, van Iperen EP, et al. Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. International journal of epidemiology. 2015. Epub 2015/05/17.

Owen CG, Kapetanakis VV, Rudnicka AR, Wathern AK, Lennon L, Papacosta O, et al. Body mass index in early and middle adult life: prospective associations with myocardial infarction, stroke and diabetes over a 30-year period: the British Regional Heart Study. BMJ open. 2015;5(9):e008105. Epub 2015/09/17.

Papachristou E, Ramsay SE, Lennon LT, Papacosta O, Iliffe S, Whincup PH, et al. The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men. BMC geriatrics. 2015;15:172. Epub 2015/12/23.

Ramsay SE, Arianayagam DS, Whincup PH, Lennon LT, Cryer J, Papacosta AO, et al. Cardiovascular risk profile and frailty in a population-based study of older British men. Heart. 2015;101(8):616-22. Epub 2014/12/07.

Ramsay SE, Morris RW, Whincup PH, Subramanian SV, Papacosta AO, Lennon LT, et al. The influence of neighbourhood-level socioeconomic deprivation on cardiovascular disease mortality in older age: longitudinal multilevel analyses from a cohort of older British men. Journal of epidemiology and community health. 2015;69(12):1224-31. Epub 2015/08/20.

Ramsay SE, Whincup PH, Watt RG, Tsakos G, Papacosta AO, Lennon LT, et al. Burden of poor oral health in older age: findings from a population-based study of older British men. BMJ open. 2015;5(12):e009476. Epub 2015/12/31.

Sartini C, Wannamethee SG, Iliffe S, Morris RW, Ash S, Lennon L, et al. Diurnal patterns of objectively measured physical activity and sedentary behaviour in older men. BMC public health. 2015;15:609. Epub 2015/07/05.

Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T, et al. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet. 2015;385(9965):351-61. Epub 2014/09/30.

Talmud PJ, Cooper JA, Morris RW, Dudbridge F, Shah T, Engmann J, et al. Sixty-five common genetic variants and prediction of type 2 diabetes. Diabetes. 2015;64(5):1830-40. Epub 2014/12/06.

Wade KH, Forouhi NG, Cook DG, Johnson P, McConnachie A, Morris RW, et al. Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. The American journal of clinical nutrition. 2015;101(1):202-9. Epub 2014/12/21.

Wannamethee SG, Atkins JL. Muscle loss and obesity: the health implications of sarcopenia and sarcopenic obesity. The Proceedings of the Nutrition Society. 2015;74(4):405-12. Epub 2015/04/29.

Wannamethee SG, Welsh P, Papacosta O, Lennon L, Whincup PH, Sattar N. Copeptin, Insulin Resistance, and Risk of Incident Diabetes in Older Men. The Journal of clinical endocrinology and metabolism. 2015;100(9):3332-9. Epub 2015/07/15.

Wannamethee SG, Whincup PH, Lennon L, Papacosta O, Shaper AG. Alcohol consumption and risk of incident heart failure in older men: a prospective cohort study. Open heart. 2015;2(1):e000266. Epub 2015/08/21.

2014

Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG. High diet quality is associated with a lower risk of cardiovascular disease and all-cause mortality in older men. J Nutr. 2014 May;144(5):673-80. doi: 10.3945/jn.113.186486. Epub 2014 Feb 26.

Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG. Sarcopenic obesity and risk of cardiovascular disease and mortality: a population-based cohort study of older men. Journal of the American Geriatrics Society. J Am Geriatr Soc. 2014 Feb;62(2):253-60. doi: 10.1111/jgs.12652. Epub 2014 Jan 15.

Atkins JL, Whincup PH, Morris RW, Wannamethee SG. Low muscle mass in older men: the role of lifestyle, diet and cardiovascular risk factors. J Nutr Health Aging. 2014 Jan;18(1):26-33. doi: 10.1007/s12603-013-0336-9.

Jefferis BJ, Whincup PH, Papacosta O, Wannamethee SG. Protective effect of time spent walking on risk of stroke in older men. Stroke 2014; 45(1):194-9.

Jefferis BJ, Sartini C, Lee IM, Choi M, Amuzu A, Gutierrez C, Casas JP, Ash S, Lennnon LT, Wannamethee SG, Whincup PH. Adherence to physical activity guidelines in older adults, using objectively measured physical activity in a population-based study. BMC Public Health. 2014 Apr 19;14(1):382. doi: 10.1186/1471-2458-14-382.

Jefferis BJ, Whincup PH, Lennon LT, Papacosta O, Goya Wannamethee S.

Physical activity in older men: longitudinal associations with inflammatory and hemostatic biomarkers, N-terminal pro-brain natriuretic Peptide, and onset of coronary heart disease and mortality. J Am Geriatr Soc. 2014 Apr;62(4):599-606. doi: 10.1111/jgs.12748. Epub 2014 Mar 17.

Ramsay SE, Whincup PH, Papacosta O, Morris R, Lennon L, Wannamethee SG. Inequalities in heart failure in older men: prospective associations between socioeconomic measures and heart failure incidence in a 10-year follow-up study. Eur Heart J. 2014 Feb;35(7):442-7. doi: 10.1093/eurheartj/eht449. Epub 2013 Oct 18.

Wannamethee SG, Welsh P, Whincup PH, Lennon L, Papacosta O, Sattar N. NT-proBNP but not copeptin improves prediction of heart failure over other routine clinical risk parameters in older men with and without cardiovascular disease: population based study. Eur J Heart Fail. 2014 Jan;16(1):25-32. doi: 10.1093/eurjhf/hft124. Epub 2013 Dec 3.

Wannamethee SG, Shaper AG, Whincup PH, Lennon L, Papacosta O, Sattar N. The obesity paradox in men with coronary heart disease and heart failure: the role of muscle mass and leptin. Int J Cardiol. 2014 Jan 15;171(1):49-55. doi: 10.1016/j.ijcard.2013.11.043. Epub 2013 Nov 23.

2013

Holmes MV, Simon T, Exeter HJ, Folkersen L, Asselbergs FW, Guardiola M, Cooper JA, Palmen J, Hubacek JA, Carruthers KF, Horne BD, Brunisholz KD, Mega JL, van Iperen EP, Li M, Leusink M, Trompet S, Verschuren JJ, et al. Secretory Phospholipase A2-IIA and Cardiovascular Disease: a Mendelian randomization study. J Am Coll Cardiol. 2013 Jul 19 S0735-1097(13)02778-2. PMID: 23916927

Jefferis BJ, Whincup PH, Welsh P, Wannamethee SG, Rumley A, Ebrahim S, Lawlor DA,Lowe GD. Prospective study of IL-18 and risk of MI and stroke in men and women aged 60-79 years: a nested case-control study. Cytokine. 2013 Feb;61(2):513-20.

Khan TA, Shah T, Prieto D, Zhang W, Price J, Fowkes GR, Cooper J, Talmud PJ, Humphries SE, Sundstrom J, Hubacek JA, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Abdollahi MR, Slooter AJ, Szolnoki Z, Sandhu M, Wareham N, Frikke-Schmidt R, Tybjærg-Hansen A, Fillenbaum G, Heijmans BT, Katsuya T, Gromadzka G, Singleton A, Ferrucci L, Hardy J, Worrall B, Rich SS, Matarin M, Whittaker J, Gaunt TR, Whincup P, Morris R, Deanfield J, Donald A, Davey Smith G, Kivimaki M, Kumari M, Smeeth L, Khaw KT, Nalls M, Meschia J, Sun K, Hui R, Day I, Hingorani AD, Casas JP. Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals. Int J Epidemiol. 2013 Apr;42(2):475-92. PMID: 23569189

Rutter MK, Sattar N, Tajar A, O'Neill TW, Lee DM, Bartfai G et al. Epidemiological evidence against a role for C-reactive protein causing leptin resistance. Eur J Endocrinol 2013; 168(1):101-106.

Singh GM, Danaei G, Farzadfar F, Stevens GA, Woodward M, Wormser D, Kaptoge S, Whitlock G, Qiao Q, Lewington S, Di Angelantonio E, Vander Hoorn S, Lawes CM, Ali MK, Mozaffarian D, Ezzati M; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group; Asia-Pacific Cohort Studies Collaboration (APCSC); Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europe (DECODE); Emerging Risk Factor Collaboration (ERFC); Prospective Studies Collaboration (PSC). The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis. PLoS One. 2013 Jul 30;8(7):e65174. PMID: 23935815

Shah T, Engmann J, Dale C, Shah S, White J, Giambartolomei C, McLachlan S, Zabaneh D, Cavadino A, Finan C, Wong A, Amuzu A, Ong K, Gaunt T, Holmes MV, Warren H, Davies TL, Drenos F, Cooper J, Sofat R, Caulfield M, Ebrahim S, Lawlor DA, Talmud PJ, Humphries SE, Power C, Hypponen E, Richards M, Hardy R, Kuh D, Wareham N, Ben-Shlomo Y, Day IN, Whincup P, Morris R, Strachan MW, Price J, Kumari M, Kivimaki M, Plagnol V, Dudbridge F, Whittaker JC, Casas JP, Hingorani AD; UCLEB Consortium. Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. PLoS One. 2013 Aug 20;8(8):e71345. PMID: 23977022

Wannamethee SG, Sattar N, Papcosta O, Lennon L, Whincup PH. Alkaline phosphatase, serum phosphate, and incident cardiovascular disease and total mortality in older men. Arterioscler Thromb Vasc Biol 2013; 33(5):1070-1076.

Wannamethee SG, Shaper AG, Whincup PH, Lennon L, Sattar N. Adiposity, adipokines, and risk of incident stroke in older men. Stroke 2013; 44(1):3-8.

Wannamethee SG, Bruckdorfer KR, Shaper AG, Papacosta O, Lennon L, Whincup PH. Plasma vitamin C, but not vitamin E, is associated with reduced risk of heart failure in older men. Circ Heart Fail. 2013 Jul;6(4):647-54.

Wannamethee SG. Significance of frequency patterns in 'moderate' drinkers for low-risk drinking guidelines. Addiction. 2013 Sep;108(9):1545-7.

2012

Angelakopoulou A, Shah T, Sofat R, Shah S, Berry DJ, Cooper J et al. Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Eur Heart J 2012; 33(3):393-407.

Di AE, Gao P, Pennells L, Kaptoge S, Caslake M, Thompson A et al. Lipid-related markers and cardiovascular disease prediction. JAMA 2012; 307(23):2499-2506.

Ghebre MA, Wannamethee SG, Rumley A, Whincup PH, Lowe GD, Morris RW. Prospective study of seasonal patterns in hemostatic factors in older men and their relation to excess winter coronary heart disease deaths. J Thromb Haemost 2012; 10(3):352-358.

Emerging Risk Factors Collaboration. Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. Int J Epidemiol 2012; 41(5):1419-1433.

Hingorani AD, Sofat R, Morris RW, Whincup P, Lowe GD, Mindell J et al. Is it important to measure or reduce C-reactive protein in people at risk of cardiovascular disease? Eur Heart J 2012; 33(18):2258-2264

Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium, Hingorani AD, Casas JP. The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet 2012; 379(9822):1214-1224.

Jefferis BJ, Whincup PH, Lennon L, Wannamethee SG. Longitudinal associations between changes in physical activity and onset of type 2 diabetes in older British men: the influence of adiposity. Diabetes Care 2012; 35(9):1876-1883.

Kaptoge S, Di AE, Pennells L, Wood AM, White IR, Gao P et al. C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med 2012; 367(14):1310-1320.

Munafo MR, Timofeeva MN, Morris RW, Prieto-Merino D, Sattar N, Brennan P et al. Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure. J Natl Cancer Inst 2012; 104(10):740-748.

Rutter MK, Sattar N, Tajar A, O'Neill TW, Lee DM, Bartfai G et al. Epidemiological evidence against a role for C-reactive protein causing leptin resistance. Eur J Endocrinol 2013; 168(1):101-106.

Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN et al. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet 2012; 379(9822):1205-1213.

Wannamethee SG, Whincup PH, Lennon L, Rumley A, Lowe GD. Fibrin D-dimer, tissue-type plasminogen activator, von Willebrand factor, and risk of incident stroke in older men. Stroke 2012; 43(5):1206-1211.

Wannamethee SG, Papacosta O, Lawlor DA, Whincup PH, Lowe GD, Ebrahim S et al. Do women exhibit greater differences in established and novel risk factors between diabetes and non-diabetes than men? The British Regional Heart Study and British Women's Heart Health Study. Diabetologia 2012; 55(1):80-87.

Wannamethee SG, Whincup PH, Shaper AG, Lennon L, Sattar N. Gamma-glutamyltransferase, hepatic enzymes, and risk of incident heart failure in older men. Arterioscler Thromb Vasc Biol 2012; 32(3):830-835.

2011

Angelakopoulou A, Shah T, Sofat R, Shah S, Berry DJ, Cooper J et al. Comparative analysis of genome-wide-association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Eur Heart J 2011 July 30.

Artigas MS, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W et al. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet 2011;43(11):1082-90.

Dudina A, Cooney MT, Bacquer DD, Backer GD, Ducimetiere P, Jousilahti P et al. Relationships between body mass index, cardiovascular mortality, and risk factors: a report from the SCORE investigators. Eur J Cardiovasc Prev Rehabil 2011 October;18(5):731-42.

Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011 October 6;478(7367):103-9.

Freathy RM, Kazeem GR, Morris RW, Johnson PC, Paternoster L, Ebrahim S et al. Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. Int J Epidemiol 2011 May 18.

Hardoon SL, Morris RW, Whincup PH, Shipley MJ, Britton AR, Masset G et al. Rising adiposity curbing decline in the incidence of myocardial infarction: 20-year follow-up of British men and women in the Whitehall II cohort. Eur Heart J 2011 June 8.

Hardoon SL, Whincup PH, Petersen I, Capewell S, Morris RW. Trends in longer-term survival following an acute myocardial infarction and prescribing of evidenced-based medications in primary care in the UK from 1991: a longitudinal population-based study. J Epidemiol Community Health 2011 September;65(9):770-4.

Jefferis BJ, Papacosta O, Owen CG, Wannamethee SG, Humphries SE, Woodward M et al. Interleukin 18 and coronary heart disease: prospective study and systematic review. Atherosclerosis 2011 July;217(1):227-33.

Jefferis BJ, Whincup PH, Welsh P, Wannamethee SG, Rumley A, Lawlor DA et al. Prospective study of circulating soluble CD40 ligand concentrations and the incidence of cardiovascular disease in a nested prospective case-control study of older men and women. J Thromb Haemost 2011 August;9(8):1452-9.

Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M et al. Blood Pressure Loci Identified with a Gene-Centric Array. Am J Hum Genet 2011 November 16.

Jones IR, Papacosta O, Whincup PH, Wannamethee SG, Morris RW. Class and lifestyle 'lock-in' among middle-aged and older men: a Multiple Correspondence Analysis of the British Regional Heart Study. Sociol Health Illn 2011 March;33(3):399-419.

Lawlor DA, Kim L, Morris R, Amuzu A, Whincup P, Ebrahim S. Survival with treated and well-controlled blood pressure: findings from a prospective cohort study. PLoS One 2011;6(4):e17792.

Ramsay SE, Whincup PH, Lennon LT, Morris RW, Wannamethee SG. Longitudinal associations of socioeconomic position in childhood and adulthood with decline in lung function over 20 years: results from a population-based cohort of British men. Thorax 2011 December;66(12):1058-64.

Ramsay SE, Morris RW, Whincup PH, Papacosta AO, Thomas MC, Wannamethee SG. Prediction of coronary heart disease risk by Framingham and SCORE risk assessments varies by socioeconomic position: results from a study in British men. Eur J Cardiovasc Prev Rehabil 2011 April;18(2):186-93.

Ramsay SE, Whincup PH, Hardoon SL, Lennon LT, Morris RW, Wannamethee SG. Social class differences in secular trends in established coronary risk factors over 20 years: a cohort study of British men from 1978-80 to 1998-2000. PLoS One 2011;6(5):e19742.

Soler AM, Wain LV, Repapi E, Obeidat M, Sayers I, Burton PR et al. Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med 2011 October 1;184(7):786-95.

Wannamethee SG, Welsh P, Whincup PH, Sawar N, Thomas MC, Gudnarsson V et al. High adiponectin and increased risk of cardiovascular disease and mortality in asymptomatic older men: does NT-proBNP help to explain this association? Eur J Cardiovasc Prev Rehabil 2011 February;18(1):65-71.

Wannamethee SG, Shaper AG, Whincup PH, Lennon L, Sattar N. Impact of diabetes on cardiovascular disease risk and all-cause mortality in older men: influence of age at onset, diabetes duration, and established and novel risk factors. Arch Intern Med 2011 March 14;171(5):404-10.

Wannamethee SG, Welsh P, Lowe GD, Gudnason V, Di AE, Lennon L et al. N-terminal pro-brain natriuretic Peptide is a more useful predictor of cardiovascular disease risk than C-reactive protein in older men with and without pre-existing cardiovascular disease. J Am Coll Cardiol 2011 June 28;58(1):56-64.

Wannamethee SG, Shaper AG, Whincup PH, Lennon L, Sattar N. Obesity and risk of incident heart failure in older men with and without pre-existing coronary heart disease: does leptin have a role? J Am Coll Cardiol 2011 October 25;58(18):1870-7.

Wannamethee SG, Papacosta O, Whincup PH, Thomas MC, Carson C, Lawlor DA et al. The potential for a two-stage diabetes risk algorithm combining non-laboratory-based scores with subsequent routine non-fasting blood tests: results from prospective studies in older men and women. Diabet Med 2011 January;28(1):23-30.

Zabaneh D, Gaunt TR, Kumari M, Drenos F, Shah S, Berry D et al. Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip. Ann Hum Genet 2011 July;75(4):456-67.

2010

Hardoon SL, Morris RW, Thomas MC, Wannamethee SG, Lennon LT, Whincup PH. Is the recent rise in type 2 diabetes incidence from 1984 to 2007 explained by the trend in increasing BMI?: evidence from a prospective study of British men. Diabetes Care 2010;33(7):1494-6.

Hardoon SL, Whincup PH, Wannamethee SG, Lennon LT, Capewell S, Morris RW. Assessing the impact of medication use on trends in major coronary risk factors in older British men: a cohort study. Eur J Cardiovasc Prev Rehabil 2010;17(5):502-8.

Jefferis BJ, Lawlor DA, Ebrahim S, Wannamethee SG, Feyerabend C, Doig M, McMeekin L, Cook DG, Whincup PH. Cotinine-assessed second-hand smoke exposure and risk of cardiovascular disease in older adults. Heart. 2010;96(11):854-9.

Ramsay S, Morris R, Whincup P, Papacosta A, Thomas M, Wannamethee S. Prediction of coronary heart disease risk by Framingham and SCORE risk assessments varies by socioeconomic position: results from a population-based study in British men. Eur J Cardiovasc Prev Rehab. In Press.

Shaper AG. Alcohol consumption decreases with the development of disease. AIM (Alcohol in Moderation) Digest Online. 2010;29(2):9.

Taylor AE, Ebrahim S, Ben-Shlomo Y, Martin RM, Whincup PH, Yarnell JW, Wannamethee SG, Lawlor DA. Comparison of the associations of body mass index and measures of central adiposity and fat mass with coronary heart disease, diabetes, and all-cause mortality: a study using data from 4 UK cohorts. Am J Clin Nutr. 2010 Mar;91(3):547-56. Epub 2010 Jan 20.

Timpson NJ, Forouhi NG, Brion MJ, Harbord RM, Cook DG, Johnson P, McConnachie A, Morris RW, Rodriguez S, Luan J, et al. Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with > 15,000 participants. Am J Clin Nutrition 2010;92(2):375-382.

Wannamethee SG, Shaper AG, Rumley A, Sattar N, Whincup PH, Thomas MC, Lowe GD. Lung function and risk of type 2 diabetes and fatal and nonfatal major coronary heart disease events: possible associations with inflammation. Diabetes Care. 2010;33(9):1990-6.

Wannamethee SG, Shaper AG. Cigarette smoking and serum liver enzymes: the role of alcohol and inflammation. Ann Clin Biochem. 2010;47(Pt 4):321-6.

Wannamethee SG, Welsh P, Whincup PH, Sawar N, Thomas MC, Gudnarsson V, Sattar N. High adiponectin and increased risk of cardiovascular disease and mortality in asymptomatic older men: does NT-proBNP help to explain this association? Eur J Cardiovasc Prev Rehabil. 2010 May 25th epub ahead of publication.

Wannamethee SG, Papacosta O, Whincup PH, Carson C, Thomas MC, Lawlor DA, Ebrahim S, Sattar N. Assessing prediction of diabetes in older adults using different adiposity measures: a 7 year prospective study in 6,923 older men and women. Diabetologia. 2010;53(5):890-8.

Wannamethee SG, Shaper AG, Whincup PH, Lennon L, Sattar N. Type 2 diabetes in older age and risk of coronary heart disease and all cause mortality: impact of age at onset, diabetes duration and established and novel risk factors. Arch Intern Med. In press.

Emerging Risk Factors Collaboration, Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, Di Angelantonio E, Ingelsson E, Lawlor DA, Selvin E, Stampfer M, Stehouwer CD, Lewington S, Pennells L, Thompson A, Sattar N, White IR, Ray KK, Danesh J. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375(9733):2215-22.

Emerging Risk Factors Collaboration, Thompson S, Kaptoge S, White I, Wood A, Perry P, Danesh J. Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies. Int J Epidemiol. 2010;39(5):1345-59.

Emerging Risk Factors Collaboration, Kaptoge S, Di Angelantonio E, Lowe G, Pepys MB, Thompson SG, Collins R, Danesh J. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet. 2010;375(9709):132-40.

Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration, Sarwar N, Sandhu MS, Ricketts SL, Butterworth AS, Di Angelantonio E, Boekholdt SM, Ouwehand W, Watkins H, Samani NJ, et al. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet. 2010;375(9726):1634-1639.