I am driven by the objective of improving clinical outcomes from molecular and cellular discoveries, to the benefit of the patient. This is reflected in my areas of academic interest that include developing biomarkers with high sensitivity and specificity to detect various forms of dementia, and their implementation in routine clinical setting with an aim to monitor the progression of the disease and treatment; relating this knowledge to further neuropathological and neuobiochemical knowledge of ageing in neurodevelopmental disorders, such as ageing and neurodegeneration in Down syndrome and autism.