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TUBE is led by Newcastle Clinical Trials Unit Newcastle University.
Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust (Ref No: 6680)
Funder: This project is funded by the National Institute for Health Research (NIHR) Heath Technology Assessment (HTA) Programme (project number 12/35/32). The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the HTA, NIHR, NHS or the Department of Health.