Publications

Publications

  1. C Correia-Melo, F DM Marques, R Anderson, G Hewitt, R Hewitt, BM Carroll, SMiwa, A Merz, MD Rushton, M Charles, D Jurk, SWG Tait, R Czapiewski, J Birch, LC Greaves, G Nelson, M Bohlooly-Y, S Rodriguez-Cuenca, A Vidal-Puig, DA Mann, G Saretzki, G Quarato, D Green, PD Adams, T von Zglinicki, VI Korolchuk, JF Passos. Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO J (2016) doi:10.15252/embj.201592862
  2. J Birch, S Victorelli, D Rahmatika, RK Anderson, K Jiwa, E Moisey, C Ward, AJ Fisher, A De Soyza, JF Passos. Telomere Dysfunction and Senescence-associated Pathways in Bronchiectasis (2016) Am J Respir Crit Care Med. Accepted
  3. B Carroll, D Maetzel, OD Maddocks, G Otten, M Ratcliff, GR Smith, EA Dunlop, JF Passos, OR Davies, R Jaenisch, AR Tee, S Sarkar, VI Korolchuk. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. Elife. (2016) ;5. pii: e11058. doi: 10.7554/eLife.11058.
  4. J Birch, RK Anderson, C Correia-Melo, D Jurk, G Hewitt, FM Marques, NJ Green, E Moisey, MA Birrell, MG Belvisi, F Black, JJ Taylor, AJ Fisher, A De Soyza, JF Passos. DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. (2015) 309(10):L1124-37. doi: 10.1152/ajplung.00293.2015.
  5. Correia-Melo C, Passos JF. Mitochondria: Are they causal players in cellular senescence? Biochim Biophys Acta. 2015 May 28. pii: S0005-2728(15)00098-5. doi: 10.1016/j.bbabio.2015.05.017.
  6. Wilson CL, Jurk D, Fullard N, Banks P, Page A, Luli S, Elsharkawy AM, Gieling RG, Chakraborty JB, Fox C, Richardson C, Callaghan K, Blair GE, Fox N, Lagnado A, Passos JF, Moore AJ, Smith GR, Tiniakos DG, Mann J, Oakley F, Mann DA. NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma Nat Commun. 2015 Apr 16;6:6818. doi: 10.1038/ncomms7818.
  7. Neganova I, Tilgner K, Buskin A, Paraskevopoulou I, Atkinson SP, Peberdy D, Passos JF, Lako M. CDK1 plays an important role in the maintenance of pluripotency and genomic stability in human pluripotent stem cells. Cell Death Dis. 2014 Nov 6;5:e1508. doi: 10.1038/cddis.2014.464.
  8. Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nat Commun. 2014 Jun 24;2:4172. doi: 10.1038/ncomms5172.
  9. Correia-Melo C, Hewitt G, Passos JF.Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence? . Longev Healthspan. 2014 Jan 16;3(1):1. doi: 10.1186/2046-2395-3-1.
  10. Hewitt G, von Zglinicki T, Passos JF.Cell sorting of young and senescent cells.Methods Mol Biol. 2013;1048:31-47. doi: 10.1007/978-1-62703-556-9_4.
  11. Ivanov A, Pawlikowski J, Manoharan I, van Tuyn J, Nelson DM, Rai TS, Shah PP, Hewitt G, Korolchuk VI, Passos JF, Wu H, Berger SL, Adams PD. Lysosome-mediated processing of chromatin in senescence.J Cell Biol. 2013 Jul 8;202(1):129-43. doi: 10.1083/jcb.201212110. Epub 2013 Jul 1.
  12. Correia-Melo C, Jurk D, Passos JF. Robust multiparametric assessment of cellular senescence. Methods Mol Biol. 2013;965:409-19. doi: 10.1007/978-1-62703-239-1_27.
  13. Passos JF, Miwa S, von Zglinicki T. Measuring reactive oxygen species in senescent cells Methods Mol Biol. 2013;965:253-63. doi: 10.1007/978-1-62703-239-1_17.
  14. Hewitt G, Jurk D, Marques FDM, Correia-Melo C, Hardy T, Gackowska A, Andreson R, Taschuk M, Mann J and JF Passos Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence  Nat Commun. 2012 Feb 28;3:708. doi: 10.1038/ncomms1708.
  15. Lawless C, Jurk D, Gillespie CS, Shanley D, Saretzki G, von Zglinicki T, Passos JF A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations. PLoS ONE 2012;7(2):e32117. Epub 2012 Feb 16.
  16. Passos JF von Zglinicki Mitochondrial dysfunction and cell senescence - skin deep into mammalian aging. Aging (Albany NY). 2012 Feb 12.
  17. I Neganova, F Vilella, SP Atkinson, M Lloret, JF Passos, T von Zglinicki, J O'Connor, D Burks, R Jones, L Armstrong, M Lako An Important Role for CDK2 in G1 to S Checkpoint Activation and DNA Damage Response in Human Embryonic Stem Cells, 2011 Stem Cells DOI: 10.1002/stem.620
  18. JF Passos, G Nelson, C Wang, T Richter, C Simillion, CJ Proctor, S Miwa, S Olijslagers, J Hallinan, A Wipat, G Saretzki, KL Rudolph, T Kirkwood and T von Zglinicki Feedback between p21 and reactive oxygen production is necessary for cell senescence Molecular Systems Biology 2010;6:347
  19. C Lawless. C Wang, A Merz, D Jurk T von Zglinicki and JF Passos Quantitative assessment of senescence markers Exp Gerontology 2010Exp Gerontol. 2010 Oct;45(10):772-8.
  20. JF Passos, C. Simillion J Hallinan, A Wipat, T von Zglinicki. Cellular Senescence Unravelling complexity 2009 Dec;31(4):353-63. doi: 10.1007/s11357-009-9108-1.
  21. MJ Birket, JF Passos, T von Zglinicki and MA Birch-Machin The Relationship between the Ageing-and Photo-Dependent T414G Mitochondrial DNA Mutation with Cellular Senescence and Reactive Oxygen Species Production in Cultured Skin Fibroblasts J Investigative Dermatology 2009 Jun;129(6):1361-6.
  22. A Tsolou, JF Passos, G Nelson, Y Arai, T von Zglinicki ssDNA fragments induce cell senescence by telomere uncapping. Exp Gerontol. 2008 Oct;43(10):892-9.
  23. JF Passos Portugal gets ready to embrace ageing research. Biogerontology. 2008 Jun;9(3):209-11.
  24. S Ahmed, JF Passos, MJ Birket, T Beckmann, H Peters, MA Birch-Machin and T von Zglinicki, G Saretzki Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci. 2008 Apr 1;121(Pt 7):1046-53.
  25. K Ksiazek, JF Passos, S Olijslagers and T von Zglinicki Mitochondrial dysfunction is a possible cause of accelerated senescence of mesothelial cells exposed to high glucose. Biochem Biophys Res Commun. 2008 Feb 15;366(3):793-9.
  26. G Saretzki, T Walter, JF Passos, B Bareth, W N Keith, R Stewart, S Atkinson, S Hoare, M Stojkovic, Armstrong, T von Zglinicki and M Lako Down-regulation of multiple stress defence mechanisms during differentiation of human embryonic stem cells Stem Cells 2008 Feb;26(2):455-64.
  27. CC Pacheco, JF Passos, AR Castro, P Moradas-Ferreira and P De Marco Role of respiration and glutathione in cadmium-induced oxidative stress in Escherichia coli K-12. Arch Microbiol. 2008 Mar;189(3):271-8.
  28. JF Passos, G Saretzki, Ahmed S, Nelson G, Richter T, H Peters, I Wappler, M Birket, G Harold, K Schaeuble, M Birch-Machin, T Kirkwood, T von Zglinicki Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biology 2007 May;5(5):e110.
  29. JF Passos, G Saretzki and T von Zglinicki DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res. 2007;35(22):7505-13.
  30. JF Passos, T von Zglinicki and TB Kirkwood Mitochondria and ageing: winning and losing in the numbers game. Bioessays. 2007 Sep;29(9):908-17.
  31. JF Passos and T von Zglinicki Methods for cell sorting of young and senescent cells. Methods Mol Biol. 2007;371:33-44.
  32. H Soleimanpour-Lichaei, I Kühl, M Gaisne, JF Passos, M Wydro, J Rorbach, R Temperley, N Bonnefoy, W Tate, R Lightowlers, S Chrzanowska-Lightowlers. mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG. Mol Cell. 2007 Sep 7;27(5):745-57.
  33. K Ksiazek, JF Passos, S Olijslagers, G Saretzki C Martin-Ruiz and T von Zglinicki Premature senescence of mesothelial cells is associated with non-telomeric DNA damage. Biochem Biophys Res Commun. 2007 Oct 26;362(3):707-11.
  34. JF Passos and T von Zglinicki Oxygen free radicals in cell senescence: are they signal transducers? Free Radic Res. 2006 Dec;40(12):1277-83.
  35. JF Passos, T von Zglinicki and G Saretzki Mitochondrial dysfunction and cell senescence: Cause or consequence? Rejuvenation Research 9(1) 64-68 (2006).
  36. Getliffe, C Martin-Ruiz, JF Passos, T von Zglinicki and CU Nwokolo Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients. Eur J Gastroenterol Hepatol. 2006 Feb;18(2):133-41.
  37. JF Passos and T von Zglinicki Mitochondria, telomeres and cell senescence Exp Gerontology 2005 40, 466-472
  38. CC Pacheco, JF Passos, P Moradas-Ferreira, P De Marco 2003 Strain PM2, a novel methylotrophic fluorescent Pseudomonas sp. FEMS Microbiol Lett. 2003 Oct 24;227(2):279-85.

Book Chapters

  • S Victorelli and JF Passos Telomeres shortening: a mere replicometer? Cellular Ageing and Replicative Senescence Volume  Healthy Ageing and Longevity Ed. Leonard Hayflick and Suresh Rattan Springer In Press
  • JF Passos and TB Kirkwood Biological and physiological aspects of aging Textbook of Geriatric Dentistry editors: Poul Holm-Pedersen, Angus Walls and Jonathan Ship Blackwell publishing 2015.
  • T von Zglinicki, G Saretzki and JF Passos Aging and Telomeres. Reference Module in Biomedical Sciences. Elsevier doi: 10.1016/B978-0-12-801238-3.00018-0. 2014
  • JF Passos and T von Zglinicki,Oxidative Stress, Telomeres and Cell Senescence book chapter on Principles of Free Radical Biomedicine editor: K Pantopoulos Nova Science Publishers, Inc in Press.
  • JF Passos and T von Zglinicki, Retrograde response, oxidative stress and cellular senescence book chapter on Oxidative stress in aging editors: F. Muller, S. Miwa, K. Beckman, Humana Press 2008; 39-52.
  • JF Passos, G Nelson and T von Zglinicki, Telomeres, Senescence, Oxidative stress and heterogeneity book chapter on Telomeres and telomerase in ageing, disease, and cancer editor: KL Rudolph, Springer 2007;43-56.