People

Mikolaj Ogrodnik

Mikolaj Ogrodnik

I am particularly interested mostly in ageing process and interventions, which increase the lifespan. Personally, I consider biogerontology one of the most important fields of research because it could help to solve the most important health problems of modern society- age-related diseases. I specialize in cellular senescence and protein aggregation processes.

Project:

My project focuses on the liver, but it relates to the more general process of damage accumulation in ageing. With age, we accumulate damaged macromolecules (DNA, protein and lipids) and senescent cells, that according to “damage theory of ageing” drive the ageing process. Dietary interventions which have been shown to increase the lifespan of mice have an impact on damage accumulation in the liver. The main goal of this project is to establish what kind of damage accumulates in mouse liver with age and how the level of damage fluctuates with changing dietary interventions.

Attended conferences about ageing:

06-10.04.2014, “Genetics of aging and longevity”, Sochi, Russia,  Oral presentation “Association with cytoskeleton mediates asymmetric inheritance of quality control inclusions bodies in mammalian cells”

10-14.03.2013 “8th European Congress of Biogeontology”, Israel, Poster presentation: “Melatonin’s and Tacrine’s Derivatives cause senescence in breast cancer cell line MCF-7”

15-16.12.2012 “Seneca 2012”, Warsaw, Poland, Poster presentation: “Antiproliferative effect of melatonin’s derivatives on breast cancer cell line MCF-7”.

22-25.04 .2012, “Genetics of aging and longevity”,  Moscow, Russia,  Poster presentation “The pleiotropic influence of reactive oxygen species”

Publications :

Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin"

PNAS, 2014, in press

 

Contact: m.ogrodnik@newcastle.ac.uk