|
|
|
Contact information
- Phone number: +44 (0)191 222 3481
- e-mail adress: Tom.Williams2 (at) newcastle.ac.uk
Work descriptionI did my Ph.D. with Mario Fares in the Genetics Department at Trinity College Dublin
on the evolution of molecular chaperones. In Newcastle, I am studying the genome
evolution of microsporidia. In general, microsporidial genomes are small and have
lost many typically eukaryotic features, both in terms of functions (protein
families) and genome organization (introns, repetitive elements). However, there is
substantial variation in genome size and composition within the microsporidia, and
we don't really understand how or why these differences exist. I am using
comparative genomics to analyse the retention and loss of these features across
reduced genomes, in the hope that we can better understand their functions in all
eukaryotes.
Tom's publications
- Rytkoenen KT, Williams TA, Renshaw GM, Primmer CR, Nikinmaa M. Molecular Evolution of the Metazoan PHD-HIF Oxygen-Sensing System. Mol Biol Evol. vol 28 p. 1913-26 (2011). pubmed
- Williams TA, Embley TM, Heinz E. Informational Gene Phylogenies Do Not Support a Fourth Domain of Life for Nucleocytoplasmic Large DNA Viruses. PLoS ONE. vol 6 p. doi:10.1371/ (2011). pubmed
- Williams TA, Codoner FM, Toft C, Fares MA. Two chaperonin systems in bacterial genomes with distinct ecological roles. Trends Genet. vol 26 p. 47-51 (2010). pubmed
- Williams TA, Fares MA. The effect of chaperonin buffering on protein evolution. Genome Biol. Evol. vol 2 p. 609-19 (2010). pubmed
- Toft C, Williams TA, Fares MA. Genome-wide functional divergence after the symbiosis of proteobacteria with insects unraveled through a novel computational approach. PLoS Comput. Biol. vol 5 p. e1000344 (2009). pubmed
- Williams TA, Wolfe KH, Fares MA. No rosetta stone for a sense-antisense origin of aminoacyl tRNA synthetase classes. Mol. Biol. Evol. vol 26 p. 445-50 (2009). pubmed
|
|