Fibrofind

FibroFind - World-class Fibrosis Research Solutions

Fibrofind is a University-based service facility embedded in the world-leading academic Newcastle Fibrosis Research Group of Newcastle University. Fibrofind provides direct intellectual input from worldwide-known fibrosis Principal Investigators who manage a skillful and talented team, experts in underlying mechanisms of fibrosis in liver, lung, kidney, heart, skin and joints.

 

Fibrofind identifies fibrogenic pathways and anti-fibrotic targets. We advise the best and most optimal research solutions to test your anti-fibrotic compounds and discuss it with you before a full detailed research service proposal is issued. We have over 20 years of experience in the fibrosis field and pride ourselves on providing the best possible advice for our clients based on our collective knowledge and extensive research experience.

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Main Study Models

Liver fibrosis
  • Methionine Choline-Deficient Diet (MCD)
  • Acute CCl4
  • Chronic CCl4
  • Bile duct ligation (BDL)
Lung and skin fibrosis
  • Bleomycin
Kidney fibrosis
  • Unilateral Ureter Obstruction (UUO)
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Key Equipment and Technologies

  • Patented precision cut liver slice technology (PCLS): enables us to keep human and rodent liver slices intact and active for seven days
  • Imaging capabilities / Digital imaging analysis
  • Laser microdissection on histological slides
  • Chromatin immunoprecipitation essays
  • DNA methylation analysis on tissues
  • qPCR
  • Hydroxyproline essays
  • All other kind of immunochemistry and molecular biology analysis