The EDETOX Database
The EDETOX database was developed during the EDETOX project by Sarah Soyei and Faith Williams at the University of Newcastle. There are Two different versions, an MS Access application, and a web-based version available at http://edetox.ncl.ac.uk.
The Database contains data that has been produced by in vitro and in vivo percutaneous penetration studies. These have been compiled from the published literature. The EDETOX project is now complete and funding has ceased.data generated during the projectwill be entered in the near future.
The information can be used to establish and validate mathematical models that have been produced to predict percutaneous penetration. The data can be filtered in a variety of ways and can be extracted in printed reports or exported to excel spreadsheets.
EDETOX Criteria
All available studies on a particular chemical have been entered on to the database and an assessment has been made as to whether information fits EDETOX criteria. In order for a study to satisfy EDETOX criteria the following must all be clearly stated:
- Chemical Concentration (concentration of chemical applied)
- Dose Volume (Volume of chemical applied to the skin)
- Loading (Amount of chemical added per unit area)
- Area (Area of skin to which the chemical was applied)
- Vehicle (Application medium)
- Species (Species of animal used in the study)
- Exposure Time (Length of time the chemical was left on the skin)
- Analytical Method (Method by which the results were determined)
- Receptor Fluid (medium that bathes the underside of the skin)
- Temperature (temperature of the receptor fluid/skin/water bath during in-vitro experiments)
The calculations performed should be clearly explained and without errors.
If the reasons why a study does not meet EDETOX Criteria are not clear, an explanation is found in the notes section of the record.