Publications
List of Publications- full papers
Williams Faith M. Evaluation and predictions of dermal absorption of toxic chemicals International Archives of Occupational and Environmental Health 2004, 77, 150-151
van der Sandt, JJM, Maas, WJM, van Burgsteden, JA, Sartorelli, P, Montomoli, L, Larese, F Payan, J-P, Limaset, JC, Carmichael, P, Kenyon, S, Robinson, E, Dick, I , Nilsen Jb, Schaller K-H, Korinth, G, Cage, S Wilkinson, SC and Williams Faith M. In vitro prediction of skin absorption of caffeine, testosterone and benzoic acid : multicentre comparison study. Regulatory Pharmacology and Toxicology 39 271-281 2004
Simon C. Wilkinson, Wilfred J.M. Maas, Jesper Bo Nielsen, Laura C. Greaves, Johannes J.M. van de Sandt, Faith M. Williams Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies submitted International Archives of Occupational and Environmental Health
Francesca Larese Filon, Giovanni Maina§, Gianpiero Adami*, Marta Venier*, Nicoletta Coceani**, Rossana Bussani°, Marilena Massiccio§, Pierluigi Barbieri* and Paolo SpinelliIn vitro percutaneous absorption of cobalt International Archives of Occupational and Environmental Health( 2004) 77 85-89
S. Kezic, W.J. Meuling, I. Jakasa Free and total urinary 2-butoxyacetic acid following dermal and inhalation exposure to 2-butoxyethanol in human volunteers International Archives of Occupational and Environmental Health in press
Sanja Kezic, Astrid Janmaat1Jacob Krüse2Aart.C. Monster1Maarten.M. Verberk 1 Percutaneous absorption of xylene vapour in volunteers during pre steady state and steady state Accepted for publication Toxicology Letters , 153, 273-282 2004,
Kezic et al Percutaneous absorption of water solution of trichloroethylene in volunteers. Paper in preparation
Kezic et al Percutaneous absorption of trichloroeethylene in volunteers during pre-steady and steady state Paper in Preparation
I.Jakasa, F. Calkoen and S. Kezic Determination of polyethylene glycols of different molecular weight in the stratum corneum Journal of Chromatography B, 811, 177-182, 2004
Sanja Kezic, Astrid Janmaat, Jacob Krüse, Aart C. Monster and Maarten M. Verberk Percutaneous absorption of m-xylene vapour in volunteers during pre- steady and steady state Toxicology Letters 153,273-282 2004
John Corish and Dara Fitzpatrick Theoretical Models of Percutaneous Absorption .International Conference on Occupational and Environmental Exposures of Skin to Chemicals: Science and Policy (2003)
Fitzpatrick D, Corish J and Hayes B (2004) Modelling skin permeability in risk assessment – the future Chemosphere 55 1309-1314
Francesca Larese1, Gianpiero Adami2, , Giovanni Maina3, Marta Venier2, Edoardo Reisenhofer1 LA VALUTAZIONE DELL’ASSORBIMENTO PERCUTANEO: RISULTATI PRELIMINARI DI UNO STUDIO REALIZZATO NELL’AMBITO DEL PROGETTO EUROPEO EDETOX Presented at Italian Society of Occupational Hygiene
D.G. Koopman, S. Kezic and M.M. Verberk. Skin reaction and recovery: a repeated sodium lauryl sulphate patch test vs. a 24-h patch test and tape stripping. British Journal of Dermatology Volume 150 Page 493 - March 2004
Nielsen JB, Grandjean P, (2004) Criteria for skin notation in different countries Am J Ind Med 45 275-280
Sartorelli, P (2002) Dermal exposure assessment in occupational medicine. Occup. Med 52 151-156
Sartorelli P, Anderson, HR, Angerer J, Corish J, Drexler, H, Goen T, Griffin, P, Hotchkiss, SAM Larese, F, Montomoli L, Perkins J Schmeiz, M van der Sandt J Williams F ( 2000) Percutaneous studies for risk assessment Environ Toxicol Pharmacol 8 133-152
Nielsen JB, Nielsen F and Sorrenson JA In vitro percutaneous penetration of five pesticides- the effects of molecular weight and solubility characteristics Annals of Occupational Hygiene accepted for publication
M. Venier, G. Adami, F. Larese, G. Maina, N. Renzi “Percutaneous absorption of 5 glycol ethers through human skin in vitro”, to be published in Toxicology in vitro
Jakasa, N. Mohammadi, J.Krüse, S. Kezic:Percutaneous absorption of neat and aqueous solutions of 2- butoxyethanol in volunteers International Archives of Occupational and Environmental Health (2004) 77, 79-84 ( PDF)
Kenyon, Susan, Bhattacharyya J, Benson, CJ and Carmichael PL (2004) Percutaneous penetration and genotoxicity of 4,4’-methylenediamine through rat and human skin in vitro Toxicology 196, 65-75
TRANSDERMAL ELECTRICAL RESISTANCE AND ABSORPTION MEASUREMENTS IN A FLOW THROUGH CELL SC WILKINSON, LC GREAVES and FM WILLIAMS PPP Presentation April 2002
HOW WELL CAN ONE EXTRAPOLATE PREDICTIONS WITH SKIN IN VITRO TO IN VIVO ABSORPTION? ARE THE DATA RELIABLE? Faith M WILLIAMS PPP 2002
Physiologically-Based Pharmacokinetic Modelling of the Skin Absorption of N-Methyl-Pyrrolidone in vivo. Mark S. Penney Abstract British Toxicology Society Sept 2002
Percutaneous Penetration studies for risk assessment Faith M Williams, , International Conference of Occupational and Environmental exposures of skin to Chemicals: Science and Policy 2002
THE USE OF PERCUTANEOUS PENETRATION DATA IN RISK ASSESSMENT: THE EC EDETOX PROJECT Sartorelli P1, Montomoli L1, Sisinni AG1, van De Sandt J2, Meuling WJA2, Maas WJM2, Larese F3, Payan JP4, Limasset JC4, Carmichael P5, Kenyon S5, Caldwell J5, Corish J6, Fitzpatrick D6, Dick I7, Payne M7, Shaller KH8, Drexler H8, , Korinth G8, Cage S9, O’Connor J9, Nielsen JB10, Kezic S11, Soyei S12, Wilkinson S12, Williams Faith.M.12 27th International Congress on Occupational Health- ICOH 2003 (Iguassu Falls, Brazil, 23-28 February 2003).
Criteria for Skin Notation in an International Perspective Jesper Bo Nielsen, and , Philippe Grandjean, International Conference of Occupational and Environmental exposures of skin to Chemicals: Science and Policy 2002
J.J.M. van de Sandt, W.J.M. Maas, J.A. van Burgsteden, P. Sartorelli, L. Montomoli, F. Larese, J.-P. Payan, J.C. Limasset, P. Carmicheal, S. Kenyon, E. Robinson, I. Dick, J.B. Nielsen, K.-H. Schaller, G. Korinth, S. Geh, S. Cage, S. Wilkinson and F.M. Williams (2002). International evaluation of the robustness of in vitro percutaneous absorption studies. Eighth International Conference ‘Perspectives in Percutaneous Penetration’, 2-6 April, 2002 (Juan -les-Pins, France). Perspectives in Percutaneous Penetration, p. 126, volume 8a (Ed. K.R. Brain and K.A. Walters).
WJA Meuling, JJM Van de Sandt and L Roza, (2002). Percutaneous Penetration of Caffeine in human volunteers: a mass balance approach Presented at Eighth International Conference ‘Perspectives in Percutaneous Penetration’, 2-6 April, 2002 (Juan -les-Pins, France). Perspectives in Percutaneous Penetration, p. 105, volume 8a (Ed. K.R. Brain and K.A. Walters).
W.J.M. Maas, J.J.M. van de Sandt and G. Korinth. Efficiency of microdialysis for the assessment of percutaneous absorption varies between test compounds. Ninth International Conference ‘Perspectives in Percutaneous Penetration’, 13-17 April, 2004 (La Grande Motte, France). Perspectives in Percutaneous Penetration, p. 98, volume 9a (Ed. K.R. Brain and K.A. Walters).
G. Korinth, J.J.M. van de Sandt, H. Drexler and W.J.M. Maas. Vergleichbarkeit von Hautpenetrationsuntersuchungen. 44th annual meeting of the Deutsche Gesellschaft für Arbeitsmedizin und Umweltmedizin, 21-24 April, Innsbruck, Austria.
J.J.M. van de Sandt. International evaluation of the robustness of in vitro percutaneous absorption studies. Oral presentation at meeting In Vitro Toxicology Industrial Platform. Zeist, The Netherlands, 24 - 25 October 2002.
J.J.M. van de Sandt. Robustness of in vitro percutaneous absorption studies. Oral presentation at the 41th congress of the European Societies of Toxicology. Florence, Italy, 28 September - 1 October 2003. Toxicology Letters 144 (suppl. 1), S 2.
W.J.M. Maas. Efficiency of microdialysis for the assessment of percutaneous absorption varies between test compounds. Oral resentation at Ninth International Conference ‘Perspectives in Percutaneous Penetration’, 13-17 April, 2004 (La Grande Motte, France). Perspectives in Percutaneous Penetration, p. 98, volume 9a (Ed. K.R. Brain and K.A. Walters).
Proceedings of the ABD (Working group for occupational and environmental dermatology (oral presentation in Heidelberg, Germany, 11.-13.September 2003): G. Korinth, T. Wellner, K. H. Schaller, H. Drexler: Bewertung der Validität der in vivo Mikrodialyse anhand von Hautpenetrationsstudien“ Dermatologie in Beruf und Umwelt (Occupational and environmental dermatology) 2003; 51(1): D27 (Abstract).
G.Adami, F.Larese, M.Venier, G.Maina, E.Reisenhofer, P. Barbieri: “Assorbimento percutaneo di polveri di cobalto: risultati di uno studio realizzato nell’ambito del progetto europeo EDETOX”, XXI Congresso Nazionale della Società Chimica Italiana, Torino 22-27 giugno 2003, Atti, Vol.1, AN-CO-057 (2003).
F. Franco, “Valutazione dell’assorbimento percutaneo di glicoleteri”, degree thesis, 2003.
Wilkinson, S.C. and Williams, F.M. (2002) Effects of experimental conditions on percutaneous absorption of glycol ethers in vitro. International Archives of Environmental and Occupational Health 75:519-527.
Wilkinson, S.C., Greaves, L.C. and Williams F.M. (2002) Transdermal electrical resistance and absorption measurements in a flow through cell. In: Perspectives in Percutaneous Penetration Vol 8B (Brain, K.R. and Walters, K.A. eds) STS Publishing, Cardiff In Press
Greaves, L.C., Wilkinson, S.C. and Williams, F.M. (2002) Factors affecting the percutaneous absorption of caffeine in vitro. Toxicology 178:65-66
Toxicokinetics and metabolism of N-[14C]methylpyrrolidone in male Sprague Dawley rats. A saturable NMP elimination process. Drug Metabolism and Disposition 30, 1418-1424, 2002
Toxicokinetics and metabolism of N-[14C]methylpyrrolidone in male Sprague Dawley rats. In vivo and in vitro percutaneous absorption. Drug Metabolism and Disposition 31, 659-669, 2003
Sartorelli P.: Dermal exposure assessment in Occupational Medicine. Occup. Med. 52: 151-156, 2002
Maina G., Larese F., Sartorelli P., Montomoli L., Boario G., Pollone A., Sisinni A.G., Bagnato E.: RISKOFDERM: The European research project for assessment of occupational skin exposure to chemicals. Med Lav 93: 73-79, 2002 (abs in English)
Montomoli L., Sisinni A.G., Cioni F., Barabesi L., Gilberti M.E., Festa D., Sartorelli P.: Evaluation of the sources of mercury absorption through the study of urinary levels in the general population. Med Lav 93: 184-188, 2002 (abs in English)
Sartorelli P., Montomoli L., Sisinni A.G., Cioni F., Barabesi L., R. Bussani R., Sartorelli E.: In vitro study on the percutaneous absorption of inorganic mercury from contaminated soil. Med Lav 93: 279-285, 2002 (abs in English)
Sartorelli P., Pistolesi P., Cioni F., Napoli R., Sisinni A.G., Bellussi L., Passali G.C., Cherubini Di Simplicio F., Flori L.: Allergic skin and respiratory disease due to polyfunctional aziridine. Med Lav, 94: 285-295, 2003 (abs in English)
Sartorelli P., Montomoli L., Sisinni A.G., Barabesi L., Bussani R., Cherubini Di Simplicio F.: Percutaneous penetration of inorganic mercury from soil: in vitro study. Bull Environ Contam Toxicol (in press)
Montomoli L., Sisinni A.G., Ferraro T., Montinaro L., Sartorelli P.: Cutaneous effects from occupational exposure to fenvalerate and biological monitoring of urinary metabolites. VIII International Conference "Perspectives in Percutaneous Penetration", Antibes Juan-Les-Pins 2-6 Aprile 2002. In Brain K.R. e Walters K.A., Perspectives of Percutaneous Penetration, Vol.8a, STS Publishing Editore, Cardiff 2002, p. 120
Montomoli L., Sisinni A.G., Cioni F., Fimiani M., Pianigiani E., Sartorelli P.: Permeability of cryopreserved and glycerolized skin: in vitro study with a flow through cell system. VIII International Conference "Perspectives in Percutaneous Penetration", Antibes Juan-Les-Pins 2-6 April 2002. In Brain K.R. e Walters K.A. (Eds) Perspectives of Percutaneous Penetration, Vol.8a, STS Publishing Editore, Cardiff 2002, p. 121
Porcelli B., Terzuoli L., Frosi B., Pagani R., Montomoli L., Romeo R., Sartorelli P.: Blood concentrations of lead and erythropoietin. Letter to the Editor, Lab. Clin Med., 139: 125, 2002
Sartorelli P., Montomoli L., Sisinni A.G., van De Sandt J., Meuling W.J.A., Maas W.J.M., Larese F., Payan J.P., Limasset J.C., Carmichael P., Kenyon S., Caldwell J., Corish J., Fitzpatrick D., Cocker J., Robinson E., Dick I., Penney M., Schaller K.H., Drexler H., Korinth G., Cage S., O'Connor J., Nielsen J.B., Kezic S.1, Soyei S., Wilkinson S., Williams F.: The use of percutaneous penetration data in risk assessment: the EU EDETOX project. 27° ICOH, Iguassu Falls - Brazil 23-28 February 2003
Sartorelli P., Scancarello G., Romeo R., Cioni F., Cassano P., Marcianò G., Battista G.: Mineralogical analysis of bronchoalveolar lavage fluid as asbestos exposure marker. 27° ICOH, Iguassu Falls - Brazil 23-28 February 2003
Papers in preparation
Corish et al An extended QSAR database. in preparation
Nielsen JB et al Effect of natural oils on penetration characteristics Paper in preparation
Kruse et al A new mechanistic model for the prediction of percutaneous absorption of finite and infinite doses in preparation
Wilkinson et al Effect of vehicle and concentration on the percutaneous penetration of pesticides
Williams et al Butoxyethanol: its dermal penetration profile from neat and aqueous solutions using in vitro and in vivo data
Williams et al How well can one extrapolate predictions with skin in vitro to in vivo absorption? Are the data reliable?
Wilkinson et al Transdermal electrical resistance and absorption measurements in a flow through cell in preparation
G. Korinth, T. Wellner, I. Jakasa, S. Kezic, J. Krüse, K.H. Schaller Assessment of percutaneous absorption of 2-butoxyethanol by microdialysis in volunteers. Paper in preparation
WJM Maas, JJM van der Sandt,and J Korinth Percutaneous absorption of toluene, 2-butoxyethanol and propoxur determined using the microdialysis technique in vitro). Paper in preparation