‘Evaluations and Predictions of Dermal Absorption of Toxic Chemicals’
The EDETOX Program is a three-year research program funded by:
Framework V,
European Union,
Quality of Life,
Environment and Health Key Action Funding.
Project Number: QLKA-2000-00196
EDETOX began on the 1st January 2001. The final report iwas submitted in 2005
Our key objectives are:
- To investigate, in a group of centres in Europe, the usefulness of in vitro models to deliver relevant data on percutaneous penetration of chemicals. The reliability and interlaboratory variation will be assessed in order to establish standards for acceptability.
- To generate data that will improve knowledge of the dermal absorption process for a series of important environmental and occupational contaminants which have health effects in man and for which percutaneous penetration may play an important role in the total internal exposure.
- To use in vitro and in vivo experimental data generated in the project to evaluate and extend existing QSAR (quantitative structure activity relationship) and PBPK (physiologically-based pharmacokinetic) models so that they can be used for the prediction of the rates of absorption and the subsequent disposition of dermal penetrants.
- Overall to develop validated in vitro experimental strategies for the quantitative measurement of the dermal absorption of chemicals and corresponding predictive computational models so that the use of animal testing will be greatly reduced in these risk assessment procedures.
- To provide relevant quantitative data which can be used directly in the risk assessment for dermal exposure, including information that will allow regulatory authorities to progress towards assignment of quantitative skin notations for potentially hazardous chemicals.
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Project Workplan
The Work programme has been divided into five work packages each with a number of participants and deliverables. The workpackages are interlinked and each Participant contributes to several workpackages. The relationship between the workpackages and responsible partners is shown in the diagram below.
